17061-53-9

Basic information

• Product Name: (R)-1-(3-Chlorophenyl)ethanamine
• Synonyms: (R)-1-(3-CHLOROPHENYL)ETHANAMINE;(R)-1-(3-CHLOROPHENYL)ETHYLAMINE;(R)-1-(3-Chlorophenyl)ethylamine, ChiPros 99%, ee 98+%;Benzenemethanamine, 3-chloro-α-methyl-, (αR)-;(R)-1-(3-Chlorophenyl)Ethylamine, Chipros, ee 98+%;(R)-3-Chloro-α-methylbenzylamine;3-chloro-a-Methyl-;(R)-1-(3-Chlorophenyl)ethylaMine, ChiPros|r, 99%, ee 98+%
• CAS NO: 17061-53-9
• Molecular Formula: C₈H₁₀ClN
• Molecular Weight: 155.62
• Mol File: 17061-53-9.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 112°C/13mm
• Flash Point: 112°C/13mm
• Appearance: /
• Density: 1.123 g/cm³
• Vapor Pressure: 0.145mmHg at 25°C
• Refractive Index: 1.551
• PKA: 8.73±0.10(Predicted)
• Water Solubility: Insoluble in water.
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: (R)-1-(3-Chlorophenyl)ethanamine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-(3-Chlorophenyl)ethanamine(17061-53-9)
• EPA Substance Registry System: (R)-1-(3-Chlorophenyl)ethanamine(17061-53-9)

Safety Data

• Hazard Codes: C,N
• Statements: 22-34-51/53
• Safety Statements: 26-36/37/39-45-61
• RIDADR: UN2735
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 17061-53-9(Hazardous Substances Data)

Usage

Uses

(R)-1-(3-Chlorophenyl)ethylamine play a very extensive role of making chirally optically active drugs and compounds. Also as intermediates.

InChI:InChI=1/C8H10ClN/c1-6(10)7-3-2-4-8(9)5-7/h2-6H,10H2,1H3/t6-/m1/s1

Upstream product

• 24358-43-8 1-(3-Chloro-phenyl)-ethylamine 
• 141-78-6 ethyl acetate 
• 109-73-9 N-butylamine 
• 99-02-5 3'-Chloroacetophenone 
• 120121-01-9 1-(m-Chlorophenyl)ethanol 
• 2856-63-5 2-Chlorophenylacetonitrile 
• 1211473-50-5 (R)-N-[(1R)-1-(3-chlorophenyl)ethyl]-2-methylpropane-2-sulfinamide 
• 127733-35-1 1-(3-chlorophenyl)ethan-1-one O-methyl oxime 
• 124-20-9 N-(3-aminopropyl)-1,4-diaminobutane 

Downstream Products

• 1025772-35-3 1-(3-bromo-4-chlorophenyl)-N-((R)-1-(3-chlorophenyl)ethyl)ethanamine 
• 1025772-16-0 3-(aminosulfonyl)-4-chloro-N-((1R)-1-(3-chlorophenyl)ethyl)benzamide 
• 1025772-14-8 (R)-3-bromo-4-chloro-N-(1-(3-chlorophenyl)ethyl)benzamide 
• 1025772-17-1 (R)-N-(1-(3-chlorophenyl)ethyl)-4-methoxy-3-(morpholinosulfonyl)benzamide 
• 1025771-23-6 (R)-N-(4-chloro-3-nitrobenzyl)-1-(3-chlorophenyl)ethanamine 
• 1025770-95-9 (R)-N-(2-chloro-5-((1-(3-chlorophenyl)ethylamino)methyl)phenyl)-5-methylisoxazole-3-carboxamide 
• 1025772-33-1 (R)-N-(3-(tert-butyldimethylsilyloxy)-4-chlorobenzyl)-1-(3-chlorophenyl)ethanamine 
• 1195985-44-4 (1R)-1-(3-chlorophenyl)-N-((1R)-1-(1-(3-chlorophenyl)-5-methoxy-1H-pyrazol-3-yl)ethyl)ethanamine 
• 1143521-06-5 (1R)-1-(3-chlorophenyl)-N-((1R)-1-(1-(4-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)ethyl)ethanamine 
• 1195985-43-3 (1R)-1-(1-(4-bromophenyl)-5-methoxy-1H-pyrazol-3-yl)-N-((R)-1-(3-chlorophenyl)ethyl)ethanamine 
• 1198107-12-8 (R)-N-(1-(3-chlorophenyl)ethyl)benzamide 

Relevant articles and documents

A Simple Biosystem for the High-Yielding Cascade Conversion of Racemic Alcohols to Enantiopure Amines

The amination of racemic alcohols to produce enantiopure amines is an important green chemistry reaction for pharmaceutical manufacturing, requiring simple and efficient solutions. Herein, we report the development of a cascade biotransformation to aminate racemic alcohols. This cascade utilizes an ambidextrous alcohol dehydrogenase (ADH) to oxidize a racemic alcohol, an enantioselective transaminase (TA) to convert the ketone intermediate to chiral amine, and isopropylamine to recycle PMP and NAD+ cofactors via the reversed cascade reactions. The concept was proven by using an ambidextrous CpSADH-W286A engineered from (S)-enantioselective CpSADH as the first example of evolving ambidextrous ADHs, an enantioselective BmTA, and isopropylamine. A biosystem containing isopropylamine and E. coli (CpSADH-W286A/BmTA) expressing the two enzymes was developed for the amination of racemic alcohols to produce eight useful and high-value (S)-amines in 72–99 % yield and 98–99 % ee, providing with a simple and practical solution to this type of reaction.

n-Butylamine as an alternative amine donor for the stereoselective biocatalytic transamination of ketones

Formal reductive amination has been a main focus of biocatalysis research in recent times. Among the enzymes able to perform this transformation, pyridoxal-5′-phosphate-dependent transaminases have shown the greatest promise in terms of extensive substrate scope and industrial application. Despite concerted research efforts in this area, there exist relatively few options regarding efficient amino donor co-substrates capable of allowing high conversion and atom efficiency with stable enzyme systems. Herein we describe the implementation of the recently described spuC gene, coding for a putrescine transaminase, exploiting its unusual amine donor tolerance to allow use of inexpensive and readily-available n-butylamine as an alternative to traditional methods. Via the integration of SpuC homologues with tandem co-product removal and cofactor regeneration enzymes, high conversion could be achieved with just 1.5 equivalents of the amine with products displaying excellent enantiopurity.

Biocatalytic transamination with near-stoichiometric inexpensive amine donors mediated by bifunctional mono- and di-amine transaminases

The discovery and characterisation of enzymes with both monoamine and diamine transaminase activity is reported, allowing conversion of a wide range of target ketone substrates with just a small excess of amine donor. The diamine co-substrates (putrescine, cadaverine or spermidine) are bio-derived and the enzyme system results in very little waste, making it a greener strategy for the production of valuable amine fine chemicals and pharmaceuticals.