170632-16-3Relevant academic research and scientific papers
Preferential inhibition of release of pro-inflammatory cytokines
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Page/Page column 7, (2008/06/13)
A method for preferentially inhibiting release of pro-inflammatory cytokines over release of anti-inflammatory cytokines using a fused pyrazolyl compound of formula (I): A is R or in which R is H, alkyl, aryl, cyclyl, heteroaryl, or heterocyclyl; each of
1-Benzyl-3-(5′-hydroxymethyl-2′-furyl)-indazole (YC-1) derivatives as novel inhibitors against sodium nitroprusside-induced apoptosis
Lien, Jin-Cherng,Lee, Fang-Yu,Huang, Li-Jiau,Pan, Shiow-Lin,Guh, Jih-Hwa,Teng, Che-Ming,Kuo, Sheng-Chu
, p. 4947 - 4949 (2007/10/03)
Antiapoptotic agents based on 1-benzyl-3-(5′-hydroxymethyl-2′-furyl)indazole (22, YC-1) derivatives were explored for effective treatment of sepsis and septic shock. We found that compound 22, 1-benzyl-3-(5′-methoxymethyl-2′-furyl)indazole (27), and 1-phe
Synthesis of 1-benzyl-3-(5′-hydroxymethyl-2′-furyl)indazole analogues as novel antiplatelet agents
Le,Lien,Huang,Huang,Tsai,Teng,Wu,Cheng,Kuo
, p. 3746 - 3749 (2007/10/03)
1-Benzyl-3-(5′-hydroxymethyl-2′-furyl)indazole (28, YC-1) was selected as the lead compound for systemic structural modification. After screening for antiplatelet activity, SARs of YC-1 analogues were established. Among these potent active derivatives, co
1-(substituted benzyl)-3-(substituted aryl)-condensed pyrazole derivatives and processes of making the same
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, (2008/06/13)
The invention pertains to a process for preparing (1-substituted benzyl)-3-(hydroxy-carbonyl aryl) condensed pyrazoles or (1-substituted benzyl)-3-(hydroxymethyl aryl) condensed pyrazoles comprising the steps of: (a) reacting compound I and compound II, or compound III and compound IV, to produce compound V, which is a substituted aryl ketone, as follows: STR1 wherein Ar2 and At3 can be, independently, STR2 R1 is H, C1-3 alkyl, or X (halogen), R3 is H, C1-3 alkyl, X (halogen), or --OR radical, and R is H or C1-3 alkyl; the process comprising the following steps of: R2 represents CH2 OR, H, COOR, C1-3 alkyl, or X (halogen); (b) reacting the compound V with a hydrazine compound to form a hydrazone compound; (c) reacting the hydrazone compound compound with trifluoride etherate (BF3 ·Et2 O) to form a 1-(substituted benzyl) 3-(substituted aryl) condensed pyraxzole, which is represented by the following formula of STR3 Compound X can be further hydrolyzed or reduced to form corresponding carboxylic acids or alcohols.
