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1707-67-1

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1707-67-1 Usage

General Description

2-(2-Chlorophenyl)-4,5-diphenylimidazole is a chemical compound with a molecular formula C21H15ClN2. It is an imidazole derivative that contains both chlorophenyl and diphenyl groups. 2-(2-Chlorophenyl)-4,5-diphenylimidazole has potential applications in the field of medicinal chemistry, as imidazoles are known for their diverse biological activities. Specifically, 2-(2-Chlorophenyl)-4,5-diphenylimidazole may have pharmacological properties such as antifungal, antibacterial, and antiparasitic activities. It is also being investigated for its potential use as a building block in organic synthesis and in the development of new drugs. Overall, this compound has garnered interest for its potential therapeutic and pharmaceutical applications.

Check Digit Verification of cas no

The CAS Registry Mumber 1707-67-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,7,0 and 7 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1707-67:
(6*1)+(5*7)+(4*0)+(3*7)+(2*6)+(1*7)=81
81 % 10 = 1
So 1707-67-1 is a valid CAS Registry Number.
InChI:InChI=1/C21H15ClN2/c22-18-14-8-7-13-17(18)21-23-19(15-9-3-1-4-10-15)20(24-21)16-11-5-2-6-12-16/h1-14H,(H,23,24)

1707-67-1Relevant articles and documents

Deep eutectic solvent for multi-component reactions: A highly efficient and reusable acidic catalyst for synthesis of 2,4,5-triaryl-1H-imidazoles

Bakavoli, Mehdi,Eshghi, Hossein,Rahimizadeh, Mohammad,Housaindokht, Mohammad Reza,Mohammadi, Ali,Monhemi, Hassan

, p. 3497 - 3505 (2015)

Efficient synthesis of 2,4,5-trisubstituted imidazoles has been achieved by three-component cyclocondensation of benzil or benzoin, an aldehyde, and ammonium acetate by use of an acidic catalyst. The catalyst is a deep eutectic mixture of choline chloride and oxalic acid that is non-toxic and biodegradable. Crucial advantages of this process are high yields, shorter reaction times, easy work-up, purification of products by non-chromatographic methods, and reusability of the catalyst.

Synthesis and properties of novel reusable nano-ordered KIT-5-N-sulfamic acid as a heterogeneous catalyst for solvent-free synthesis of 2,4,5-triaryl-1H-imidazoles

Mirsafaei, Razieh,Heravi, Majid M.,Ahmadi, Shervin,Hosseinnejad, Tayebeh

, p. 418 - 429 (2016)

A novel silica-bonded propyl-N-sulfamic acid nanocatalyst (NHSO3H-KIT-5) supported on modified silica mesopore KIT-5 as an organic-inorganic hybrid with high specific surface area was successfully prepared. The 3-aminopropyltriethoxysilane (APTES) on KIT-5 was reacted with chlorosulfonic acid and accurately characterized by the FT-IR, XRD, SEM, EDAXS, and TGA techniques. This heterogeneous and recyclable catalyst catalyzed one pot, multicomponent condensation of benzil, aromatic aldehydes, and ammonium acetate in the presences of 0.05 g of nanocatalyst under solvent-free conditions to afford triaryl-imidazoles in excellent yields. This catalyst showed high catalytic activity under green conditions. This reaction was performed under open air conditions and required no special reaction conditions or chromatographic separation for purification.

Sodium bisulfite as an efficient and inexpensive catalyst for the one-pot synthesis of 2,4,5-triaryl-1H-imidazoles from benzil or benzoin and aromatic aldehydes

Sangshetti, Jaiprakash N.,Kokare, Nagnnath D.,Kotharkar, Sandeep A.,Shinde, Devanand B.

, p. 125 - 127 (2008)

2,4,5-Triaryl-1H-imidazoles were efficiently synthesized from benzoin or benzil, ammonium acetate, and aromatic or heteroaromatic aldehydes in the presence of sodium bisulfite as catalyst. The present protocol offers significant improvements for the synthesis of 2,4,5-triaryl-1H-imidazoles with regard to yield of products, simplicity in operation, and cheap catalyst.

A new nanocomposite catalyst based on clay-supported heteropolyacid for the green synthesis of 2,4,5-trisubstituted imidazoles

Masteri-Farahani,Ezabadi,Mazarei,Ataeinia,Shahsavarifar,Mousavi

, (2020)

Intercalation of cetyltrimethylammonium (CTA+) cations within the nanolayers of montmorillonite (MMT) clay followed by reaction with Keggin-type phosphomolybdic acid (PMo) resulted in the synthesis of (CTA)3PMo-MMT nanocomposite catalyst. The prepared nanocomposite catalyst was characterized using different physicochemical methods such as Fourier-transform infrared and inductively coupled plasma–optical emission spectroscopies, X-ray diffraction, and nitrogen adsorption–desorption (Brunauer–Emmett–Teller method) analyses. Characterization techniques demonstrated the intercalation of (CTA)3PMo species into the nanolayers of MMT. The resulting (CTA)3PMo-MMT nanocomposite catalyst efficiently catalyzed the synthesis of 2,4,5-trisubstituted imidazoles under solvent-free conditions. The efficiency is due to the fact that the presence of CTA+ species makes the nanocomposite catalyst hydrophobic and facilitates the accessibility of hydrophobic reactants to active sites in the course of the reaction. High activity and selectivity were achieved in the presence of the prepared nanocomposite catalyst. The nanocomposite catalyst was readily isolated from the reaction mixture using simple filtration, washed with ethanol, and recycled five times without a major loss of activity.

Sulfamic acid as an efficient and cost-effective catalyst for the synthesis of 2,4,5-triarylimidazoles and 2-arylphenanthrimidazoles

Peng, Hua-Nan,Peng, Xiao-Ming,Zheng, Da-Gui,Yu, Fei,Rao, Min

, p. 223 - 226 (2011)

A simple and efficient synthesis of 2,4,5-triarylimidazoles and 2-arylphenanthrimidazoles was developed using the onepot, three-component condensation reaction of an aromatic aldehyde, benzil or 9,10-phenanthroquinone and ammonium acetate in refluxing ethanol in the presence of the catalyst sulfamic acid. 2011 · Copyright by Walter de Gruyter.

Homoselective synthesis of 5-substituted 1H-tetrazoles and one-pot synthesis of 2,4,5-trisubstuted imidazole compounds using BNPs@SiO2-TPPTSA as a stable and new reusable nanocatalyst

Khodamorady, Minoo,Ghobadi, Nazanin,Bahrami, Kiumars

, (2021/02/22)

Considering the importance of tetrazole and imidazole derivatives in pharmacy, industry, and explosives, BNPs@SiO2-TPPTSA was easily prepared and used as an effective, stable, and renewable nanocatalyst for the homoselective synthesis of different 5-substituted 1H-tetrazoles and atom economic synthesis of 2,4,5-trisubstituted-1H-imidazoles in solventless conditions. BNPs@SiO2-TPPTSA was characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray diffraction (XRD), energy dispersive X-ray analysis (EDX), thermal gravimetric-differential thermal analysis (TGA-DTA), mapping, pH analysis, and Fourier transform infrared (FT-IR) techniques. Furthermore, the catalyst recycled for at least sequential five loads without a remarkable drop-in catalytic activity.

Magnetic nanoparticle-supported sulfonic acid as a green catalyst for the one-pot synthesis of 2,4,5-trisubstituted imidazoles and 1,2,4,5-tetrasubstituted imidazoles under solvent-free conditions

Amoozadeh, Ali,Kolvari, Eskandar,Sakhdari, Mahnaz

, p. 71 - 78 (2021/10/30)

In this work, magnetic nanoparticle-supported sulfonic acid (γ-Fe2O3-SO3H) is used as an efficient catalyst in the synthesis of 2,4,5-trisubstituted imidazoles and 1,2,4,5-tetrasubstituted imidazoles in a short time (40-70 min for trisubstituted imidazoles and 30-40 min for tetrasubstituted imidazoles) and high-purity products were obtained (92-98% for trisubstituted imidazoles and 94-98% for tetrasubstituted imidazoles) in simple multicomponent reactions. The structure of these products was confirmed via FT-IR and NMR. Green and recyclable catalysts, eco-friendly and solvent-free conditions, high catalytic activity, shorter reaction time, easy recovery by an external magnet, high purity, and excellent yields are some features of these reactions.

Expeditious and Highly Efficient One-Pot Synthesis of Functionalized Imidazoles Catalyzed by Sulfated Polyborate

Indalkar, Krishna,Malge, Sanjay S.,Mali, Anil S.,Chaturbhuj, Ganesh U.

, p. 387 - 396 (2021/07/26)

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