170707-46-7Relevant academic research and scientific papers
N,N-BRIDGED, NITROGEN-SUBSTITUTED CARBACYCLIC INDOLOCARBAZOLES AS PROTEIN KINASE INHIBITORS
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Page 43, (2010/02/07)
The present invention relates to novel protein kinase inhibitors with advantageous pharmaceutical properties, methods for their preparation, intermediates thereof and pharmaceutical compositions comprising the same, reagents containing the same, and methods of using the same as therapeutics, particularly in CNS diseases.
Design and implementation of an efficient synthetic approach to furanosylated indolocarbazoles: Total synthesis of (+)- and (-)-K252a
Wood, John L.,Stoltz, Brian M.,Dietrich, Hans-Jürgen,Pflum, Derek A.,Petsch, Dejah T.
, p. 9641 - 9651 (2007/10/03)
The first total synthesis of the natural product (+)-K252a (2) has been achieved in 12 steps from commercially available materials, with a longest linear sequence of seven steps and an overall yield of 21%. The synthetic strategy employs novel rhodium carbenoid chemistry in the construction of both the indolocarbazole aglycon (4) and the carbohydrate moiety (9).
The Total Synthesis of (+/-)K252a
Lowinger, Timothy B.,Chu, Jingxi,Spence, Patrick L.
, p. 8383 - 8386 (2007/10/02)
The total synthesis of (+/-)K252a (1) has been achieved following a convergent approach in which an acid-catalyzed bis-glycosidation reaction serves as a key step.
