17072-92-3Relevant articles and documents
Concise Total Synthesis and Antifungal Activities of Fusaric Acid, a Natural Product
Huang, Bin Bin,Liu, Ya Yi,Zhu, Peng Fei,Jiang, Yi Cheng,Ouyang, Ming-An
, (2020)
The total synthesis of a natural product alkaloid fusaric acid (FA), which exhibits herbicide, fungicide, insecticide and even diverse notable pharmacological activities, was accomplished in four steps using commercially available materials. The synthesis, based on a unified and flexible strategy using 6-bromonicotinaldehyde as a common intermediate, is concise, convergent, practical and can be carried out on a two-gram scale. This approach could be readily applicable to the synthesis of its analogues. In addition, FA had a wide range of inhibitory activities against 14 plant pathogenic fungi in this study, which demonstrated that as a leading compound, and it has great potential to be further developed as an agricultural fungicide.
Fusaric and 9,10-dehydrofusaric acids and their methyl esters from Fusarium nygamai
Capasso, Renato,Evidente, Antonio,Cutignano, Adele,Vurro, Maurizio,Zonno, Maria Chiara,Bottalico, Antonio
, p. 1035 - 1039 (1996)
Fusaric and 9,10-dehydrofusaric acids and their corresponding methyl esters were isolated from the culture filtrates of Fusarium nygamai. The methyl esters were characterized by chemical and spectroscopic methods and reported here for the first time as naturally occurring products. When assayed on tomato leaves and seedlings at 2.7 × 10-3 and 2 × 10-4 M, respectively, fusaric and 9,10-dehydrofusaric acids and their methyl esters showed wide chlorosis rapidly evolving into necrosis as well as a strong inhibition of root elongation, respectively. When assayed at 10-4 M on brine shrimps (Artemia salina), fusaric and 9,10-dehydrofusaric acids did not prove to be toxic, while their methyl esters showed a toxicity level of 50%, expressed as mortality. Copyright
Renal-selective prodrugs for control of renal sympathetic nerve activity in the treatment of hypertension
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Page/Page column 100-101, (2010/11/30)
Renal-selective prodrugs are described which are preferentially converted in the kidney to compounds capable of inhibiting synthesis of catecholamine-type neurotransmitters involved in renal sympathetic nerve activity. The prodrugs described herein are de