Novel cytokine production inhibitors produced by a basidiomycete, Marasmiellus sp.

Article abstract of DOI:10.7164/antibiotics.54.703

New cytokine production inhibitors, CJ-14,877 (I) and CJ-14,897 (II), were isolated from the fermentation broth of a basidiomycete, Marasmiellus sp. CL21624. Their structures were determined to be methyl-(7R,8S)-5-(7,8-dihydroxypropyl)pyridine-2-carboxylate and methyl-(7R,8S)-5-(8-acetoxy-7-hydroxyprophyl)pyridine-2-carboxylate, respectively, by spectroscopic analyses. These compounds showed inhibitory activities for lipopolysaccharide-induced production of interleukin-1β and tumor necrosis factor-α in human whole blood with IC₅₀ values of the range from 0.059 to 2.6 μM.