170856-71-0

Upstream product

• 25145-43-1 2-phenylpropionyl chloride 
• 90719-32-7 (S)-4-Benzyl-2-oxazolidinone 
• 492-37-5 hydratropic acid 
• 77943-39-6 4-methyl-5-phenyloxazolidin-2-one 
• 219951-25-4 (+/-)-pentafluorophenyl 2-phenylpropionate 
• 264621-69-4 ethyl (S)-2-oxooxazolidinine-4-carboxylate 
• 54705-41-8 (5R)-5-phenyl-1,3-oxazolidin-2-one 
• 104266-89-9 (S)-4-benzyl-3-phenylacetyl-2-oxazolidinone 
• 74-88-4 methyl iodide 

Downstream Products

• 28645-07-0 (S)-methyl 2-phenylpropanoate 
• 286967-31-5 2(S)-phenyl-1-propanol methanesulfonate 
• 147514-19-0 S-(-)-1-bromo-2-phenylpropane 
• 286967-32-6 1-trimethylsilyloxy-3(S)-[2(S)-phenyl-1-propyl]-5-(R)-methyl-1-cyclohexene 
• 37778-99-7 (S)-2-phenyl-1-propanol 

Relevant academic research and scientific papers

Resolution of pentafluorophenyl 2-phenylpropanoate using combinations of quasi-enantiomeric oxazolidin-2-ones

The kinetic, mutual and parallel resolution of a series of structurally related active esters derived from 2-phenylpropanoic acid using a combination of quasi-enantiomeric oxazolidin-2-ones is discussed.

Resolution of pentafluorophenyl esters using oxazolidin-2-ones

A series of structurally related racemic pentafluorophenyl active esters were resolved using an equimolar amount of (S)-4-phenyloxazolidin-2-one. The levels of diastereocontrol were found to be excellent (80-96% de) at ～40% conversion.

Investigations into the parallel kinetic resolution of 2-phenylpropanoyl chloride using quasi-enantiomeric oxazolidinones

The resolution of 2-phenylpropanoyl chloride using an equimolar combination of quasi-enantiomeric oxazolidinones is discussed. The levels of diastereoselectivity were found to be dependent upon the structural nature of the metallated oxazolidinone, temperature and metal counter-ion.

Copper(II)-catalyzed kinetic resolution of (±)-2-arylpropionic acids with chiral N-trimethylsilyloxazolidin-2-one

The reaction between (±)-2-arylpropanoyl chlorides 1 (2 equiv.) and enantiopure N-trimethylsilyloxazolidin-2-one 2 in the presence of a catalytic amount of CuCl2 in hexane affords the corresponding N-acyloxazolidin-2-one in good chemical yields (97%) with up to 50% de.