182370-37-2Relevant academic research and scientific papers
Synthesis and chemical and enzymatic reactivity of thymidine 3′-O- and 5′-O-phosphorofluoridothioates
Misiura, Konrad,Szymanowicz, Daria,Stec, Wojciech J.
, p. 515 - 516 (1998)
5′-O- or 3′-O-Protected thymidine 3′-O- or 5′-O-(2-thiono-1,3,2-oxathiaphospholanes) react with triethylammonium fluoride in a presence of DBU and furnish, after deprotection, thymidine 3′-O- and 5′-O-phosphorofluoridothioates; the latter undergoes stereo
Synthesis of phosphorofluoridates and phosphorofluoridothioates via the phosphoramidite approach
Dabkowski, Wojciech,Tworowska, Izabela
, p. 866 - 874 (2007/10/03)
We present a very efficient synthetic procedure leading to the phosphorofluoridates RO-P(O)(OH)F 1 or phosphorofluoridothioates RO-P(S)(OH)F 2, which is based on the intermediary of fluorophosphoramidites (RO)P(F)N iPr2 5 [R = 9-(hyd
Novel phosphitylating reagents containing a phosphorus-fluorine bond and their application in efficient synthesis of phosphorofluoridates and phosphorofluoridothionates
Dabkowski, Wojciech,Tworowska, Izabela
, p. 2462 - 2469 (2007/10/03)
Novel phosphitylating reagents containing a P-F bond are obtained in excellent yield from commercial materials. They react with alcohols at 20 °C in neutral solvents in the presence of tetrazole, chlorotrimethylsilane or benzoyl chloride to give the inter
First Synthesis of Nucleosidyl Phosphorofluoridothioates and a Convenient Synthesis of Nucleosidyl Phosphorofluoridates
Dabkowski, Wojciech,Tworowska, Izabela
, p. 727 - 728 (2007/10/03)
The first synthesis of 3'- or 5'-nucleosidyl phosphorofluoridothioates RO-P(S)(OH)F have been accomplished via nucleosidyl phosphoramidofluoridates RO-P(NPr12)F.An analogous convenient procedure has been employed to prepare 3'- or 5'-nucleosidy
