17109-22-7Relevant academic research and scientific papers
Nickel-catalyzed sp3 C-H bond activation from decarboxylative cross-coupling of α,β-unsaturated carboxylic acids with amides
Zhang, Jia-Xiang,Wang, Yan-Jing,Wang, Nai-Xing,Zhang, Wei,Bai, Cui-Bing,Li, Yi-He,Wen, Jia-Long
, p. 1621 - 1625 (2014/07/08)
Nickel-catalyzed functionalization of C(sp3)-H bonds adjacent to a nitrogen atom in amides through decarboxylative cross-coupling of α,β-unsaturated carboxylic acids is reported. A possible reaction mechanism is proposed that involves radical intermediate species. Georg Thieme Verlag Stuttgart, New York.
Oxidative coupling of alkenes with amides using peroxides: Selective amide C(sp3)-H versus C(sp2)-H functionalization
Yang, Xu-Heng,Wei, Wen-Ting,Li, Hai-Bing,Song, Ren-Jie,Li, Jin-Heng
supporting information, p. 12867 - 12869 (2014/12/11)
A new oxidative coupling of unactivated terminal alkenes with amides using peroxides is described, in which mono- and difunctionalization of alkenes are selectively achieved. In this reaction with amides, the chemoselectivity toward the functionalization of the C(sp3)-H bonds adjacent to the nitrogen atom or the functionalization of the carbonyl C(sp2)-H bonds across alkenes relies on the reaction conditions. This journal is
Functionalization of amides via copper-catalyzed oxyalkylation of vinylarenes and decarboxylative alkenylation of sp3 C-H
Yan, Hong,Lu, Linhua,Rong, Guangwei,Liu, Defu,Zheng, Yang,Chen, Jie,Mao, Jincheng
, p. 7103 - 7111 (2014/08/18)
An efficient protocol was developed to prepare a series of derivatives from amides by copper-catalyzed oxyalkylation of vinylarenes and decarboxylative alkenylation of sp3 C-H. This method is simple, practical, and inexpensive.
NEW SYNTHESES OF α-N-ALKYLACETAMIDOMETHYLATED CARBONYL COMPOUNDS
Ikeda, Kiyoshi,Terao, Yoshiyasu,Sekiya, Minoru
, p. 1156 - 1159 (2007/10/02)
Reaction of silyl enol ethers of ketones and aldehydes with 1,3,5-trialkylhexahydro-1,3,5-triazines in the presence of acetyl chloride and titanium tetrachloride afforded α-N-alkylacetamidomethylated carbonyl compounds.Thus, the reaction provides a convenient, general method for introduction of the N-alkylacetamidomethyl moiety at a position α to a carbonyl group.Keywords: N-alkylamidomethylation; 1,3,5-trialkylhexahydro-1,3,5-triazine; acetyl chloride; titanium tetrachloride; silyl enol ether
