1712-84-1Relevant academic research and scientific papers
Thermoinduced Free-Radical C-H Acyloxylation of Tertiary Enaminones: Catalyst-Free Synthesis of Acyloxyl Chromones and Enaminones
Guo, Yanhui,Xiang, Yunfeng,Wei, Li,Wan, Jie-Ping
, p. 3971 - 3974 (2018)
In this paper, the direct acyloxylation of the α-C(sp2)-H bond in tertiary β-enaminones is accomplished under catalyst-free conditions and ambient temperature by using aroyl peroxides as coupling partners. By means of a thermoinduced free-radical pathway, the present method enables facile and efficient synthesis of both acyloxylated chromones and enaminones.
Uncatalyzed, on water oxygenative cleavage of inert C-N bond with concomitant 8,7-amino shift in 8-aminoquinoline derivatives
Botla, Vinayak,Pilli, Navyasree,Malapaka, Chandrasekharam
supporting information, p. 1735 - 1742 (2019/04/08)
Oxygenative cleavage of an inert CAr-NH2 bond with concomitant 1,2 amine migration in 8-aminoquinoline derivatives is reported in water at room temperature. The reaction is highly atom- and step-economical as both C- and N-containing fragments of the C-N bond cleavage are incorporated into the target molecule and is effected without the need for N-oxide. The reaction is scalable to gram level, and the products are useful as electrophilic partners for coupling reactions, ligands in catalysis and bioactive compounds.
Iron(iii)-catalyzed chelation assisted remote C-H bond oxygenation of 8-amidoquinolines
Vinayak, Botla,Navyasree, Pilli,Chandrasekharam, Malapaka
, p. 9200 - 9208 (2017/11/14)
Iron catalyzed site selective and chelation assisted C-H functionalization in 8-amidoquinolines is achieved. The remote C5-benzoxylation with benzoyl peroxide produced a variety of potentially bioactive 8-arylcarboxamido-5-benzoyloxy quinoline derivatives. The efficiency of the reaction reflects from the wide substrate scope with electronic differentiation on carboxamide and acyl peroxide in addition to tolerance of halo-substitutions on either of the aryls. The reaction is additive, silver free and proceeds without the exclusion of air or moisture.
A highly efficient Pd-catalyzed decarboxylative ortho-arylation of amides with aryl acylperoxides
Li, Dengke,Xu, Ning,Zhang, Yicheng,Wang, Lei
supporting information, p. 14862 - 14865 (2014/12/11)
An efficient Pd-catalyzed decarboxylative ortho-arylation of amides with aryl acylperoxides was developed. A variety of anilides reacted with aryl acylperoxides to afford the corresponding ortho-arylation products, and N-methoxyarylamides generated phenanthridinones. This journal is
Bimetallic reductive elimination from dinuclear Pd(III) complexes
Powers, David C.,Benitez, Diego,Tkatchouk, Ekaterina,Goddard, William A.,Ritter, Tobias
supporting information; experimental part, p. 14092 - 14103 (2011/01/09)
In 2009, we reported C-halogen reductive elimination reactions from dinuclear Pd(III) complexes and implicated dinuclear intermediates in Pd(OAc)2-catalyzed C-H oxidation chemistry. Herein, we report results of a thorough experimental and theor
Palladium-catalyzed decarboxylative arylation of C-H bonds by aryl acylperoxides
Yu, Wing-Yiu,Sit, Wing Nga,Zhou, Zhongyuan,Chan, Albert S.-C.
supporting information; experimental part, p. 3174 - 3177 (2009/11/30)
A Pd(OAc)2-catalyzed protocol for decarboxylative arylation of aromatic C-H bond was developed using aryl acylperoxides as inexpensive aryl sources. Substrates containing pyridyl, oxime, and oxazoline groups undergo effectively ortho-selective C-H arylation with excellent functional group tolerance. This arylation should begin by directing-group-assisted cyclopalladation, followed by the reaction of the palladacycle with aryl radicals generated in situ by thermal decomposition of the peroxides.
