17130-63-1

Usage

Uses

Used in Pharmaceutical Industry:
(2Z)-2-(hydroxymethylidene)cholestan-3-one is used as a potential pharmaceutical agent for its possible biological activity. (2Z)-2-(hydroxymethylidene)cholestan-3-one's unique structure and derivation from cholesterol suggest it may have roles in the development of new drugs or therapies, particularly given its potential interactions with biological systems.
Used in Research and Development:
In the field of scientific research, (2Z)-2-(hydroxymethylidene)cholestan-3-one serves as a subject of study for understanding its chemical properties, mechanisms of action, and potential applications. This research could lead to the discovery of new uses for the compound in various industries, including medicine, agriculture, and materials science.

Upstream product

• 60-29-7 diethyl ether 
• 110-45-2 isopentyl formate 
• 566-88-1 dihydrocholesterone 
• 141-52-6 sodium ethanolate 
• 109-94-4 formic acid ethyl ester 
• 124-41-4 sodium methylate 
• 71-43-2 benzene 
• 1864-94-4 phenyl formate 
• 107-31-3 Methyl formate 
• 566-88-1 (5S,8R,9S,10S,13R,14S,17S)-17-(1,5-Dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-one 
• 601-53-6 coprostanone 
• 638-49-3 n-pentyl formate 

Downstream Products

• 22599-96-8 (3β,5α)-2-methylene-cholestan-3-ol 
• 76064-31-8 C₃₄H₅₁NO₃S 
• 76043-43-1 C₃₄H₅₁NO₃S 
• 111300-91-5 3β-benzoyloxy-2β-bromomethyl-5α-cholestane 
• 111300-90-4 3α-benzoyloxy-2β-bromomethyl-5α-cholestane 

Relevant academic research and scientific papers

The supertristeroids: Large, chiral, molecular bowls prepared by trimerization of pentacyclic steroidal ketones

(Chemical Equation Presented) Robinson annulation of coprostanone (1) at the 2,3- and 3,4-positions gave two pentacyclic enones (7 and 10) that contain A/B-cis-fused ring junctions. Reduction of these enones gave the pentacyclic steroidal ketones 2α,3β- (8) and 2α,3α-(3′- oxocyclohexano)-5β-cholestane (9) and 4α,3β- (11) and 4α,3α-(3′-oxocyclohexano)-5β-cholestane (12). The structures of compounds 8, 9, and 11 were unambiguously established by X-ray analysis. TiCl4-promoted trimerization of compounds 8 and 11 gave the "supertristeroids" 4 and 5, respectively: large (C93) chiral, hydrocarbon clefts with C3-symmetric pockets approximately 12 A in diameter.

Synthesis and substance P receptor binding activity of androstano[3,2- b]pyrimido[1,2-a]benzimidazoles

Several heterosteroids containing a dihydroethisterone skeleton were prepared and shown to displace substance P in a receptor binding assay. Further biochemical (kinetic and Scatchard analyses) and pharmacological evaluation (substance P-induced plasma extravasation and salivation in the rat) of a representative example in this series (5a) established that these compounds are competitive antagonists at the substance P receptor.

Resolution of conflicting migratory reports in ring expansion of 3-keto steroids to oxygen and nitrogen

The migration of C-2 and/or C-4 to O or N in the Beckmann, Schmidt, and Baeyer-Villiger reactions of 3-keto steroids has been studied with the aid of (13)Cmr spectroscopy.Authentic specimens of the eight possible lactone and lactam products from both 5α- and 5β-cholestan-3-one have been prepared; their physical properties and 13Cmr assignments are given.Seven ring expansion reactions reported to give only one product have been found to give both possible migration products.The much studied reactions of 5α-cholestan-3,6-dione and its derivatives have been reexamined.The results emphasize again the necessity of using 13C spectra both as an analytical tool and as the best criterion of purity in work with these molecules.