171978-60-2

Basic information

• Product Name: Carbamic acid, [(1S)-1-[[[(1S)-1-(hydroxymethyl)-2-phenylethyl]amino]carbonyl]-3-methyl butyl]-, 1,1-dimethylethyl ester
• CAS NO: 171978-60-2
• Molecular Formula: C20H32N2O4
• Molecular Weight: 364.485
• Mol File: 171978-60-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [(1S)-1-[[[(1S)-1-(hydroxymethyl)-2-phenylethyl]amino]carbonyl]-3-methyl butyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1S)-1-[[[(1S)-1-(hydroxymethyl)-2-phenylethyl]amino]carbonyl]-3-methyl butyl]-, 1,1-dimethylethyl ester(171978-60-2)
• EPA Substance Registry System: Carbamic acid, [(1S)-1-[[[(1S)-1-(hydroxymethyl)-2-phenylethyl]amino]carbonyl]-3-methyl butyl]-, 1,1-dimethylethyl ester(171978-60-2)

Safety Data

• Hazardous Substances Data: 171978-60-2(Hazardous Substances Data)

Upstream product

• 3182-95-4 L-Phenylalaninol 
• 66866-44-2 Boc-Leu-O-COO-isoBu 
• 24424-99-5 di-tert-butyl dicarbonate 
• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 200937-21-9 N-tert-butoxycarbonyl-L-leucine monohydrate 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 15136-32-0 (N-(tert-butoxycarbonyl)-L-leucinyl)-L-phenylalanine methyl ester 
• 61-90-5 L-leucine 

Downstream Products

• 1414493-21-2 tert-butyl (2S,3S,6S)-3-benzyl-2-(iodomethyl)-6-isobutyl-5-oxopiperazine-1-carboxylate 

Relevant articles and documents

Synthesis of the Nonribosomal Peptide Phevalin and Analogs

Phevalin, a cyclic nonribosomal peptide produced by Staphylococcus aureus, has intriguing biological properties. A synthetic route to access phevalin and similar pyrazinone natural products tyrvalin, leuvalin, phileucin, and a few synthetic analogs is described. The reaction sequence involves a one-pot carbamate deprotection/imine formation/aerobic oxidation to form the pyrazinone-containing products.

An efficient entry to highly substituted chiral 2-oxopiperazines from α-amino acids via iodocyclization

A short and stereoselective route for the synthesis of 2-oxopiperazines is presented starting from different naturally abundant α-amino acids. The key synthetic steps involved amide coupling, Wittig reaction, HWE olefination, aza-Michael reaction, iodocyc

Chemotactic peptide analogues: Synthesis and chemotactic activity of N-formyl-Met-Leu-Phe analogues containing (S)-phenylalaninol derivatives

The synthesis and the biological activity towards human neutrophils of some N-formyl-Met-Leu-Phe-OMe analogues containing (S)-phenylalaninol (Pheol) or its derivatives in place of the native phenylalanine are reported. While the analogue containing Pheol (4) was found to be devoid of significant biological activity, its ester 3 and 5, although inactive as chemoattractants, are able to strongly stimulate superoxide production and are active with a lower efficacy in the lysozyme release.