1721-25-1

Basic information

• Product Name: Ethanone, 1-(2,6-dimethyl-3-pyridinyl)- (9CI)
• Synonyms: Ethanone, 1-(2,6-dimethyl-3-pyridinyl)- (9CI);3-Acetyl-2,6-lutidine;1-(2,6-diMethyl-3-pyridinyl)-Ethanone;2,6-DiMethyl-3-acetylpyridine;2,6-DiMethyl-3-pyridyl Methyl Ketone;1-(2,6-diMethyl-3-pyridine)ethanone
• CAS NO: 1721-25-1
• Molecular Formula: C₉H₁₁NO
• Molecular Weight: 149.18974
• Product Categories: ACETYLGROUP;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 1721-25-1.mol
• Article Data: 7

Chemical Properties

• Melting Point: 34-35 °C
• Boiling Point: 240.172 °C at 760 mmHg
• Flash Point: 105.075 °C
• Appearance: /
• Density: 1.017 g/cm³
• Storage Temp.: 2-8°C
• PKA: 4.88±0.10(Predicted)
• CAS DataBase Reference: Ethanone, 1-(2,6-dimethyl-3-pyridinyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(2,6-dimethyl-3-pyridinyl)- (9CI)(1721-25-1)
• EPA Substance Registry System: Ethanone, 1-(2,6-dimethyl-3-pyridinyl)- (9CI)(1721-25-1)

Safety Data

• Hazardous Substances Data: 1721-25-1(Hazardous Substances Data)

Usage

Uses

As a tri-substotuted pryidine derivative, 3-Acetyl-2,6-lutidine can be used in the preparation of histamine H3 antagonists.

Upstream product

• 1118-66-7 4-amino-3-penten-2-one 
• 5436-21-5 acetylacetaldehyde dimethyl acetal 
• 69190-65-4 1,1,3-triethoxy-but-2-ene 
• 123-54-6 acetylacetone 
• 50-00-0 formaldehyd 
• 18312-45-3 propan-2-one O-acetyl oxime 
• 19788-38-6 3,5-Dimethyl-4-(3-oxobutyl)isoxazol 
• 78-94-4 methyl vinyl ketone 
• 29214-57-1 3-acetylheptane-2,6-dione 
• 5930-98-3 4-trimethylsilyl-3-butyn-2-one 
• 75-29-6 isopropyl chloride 
• 75-36-5 acetyl chloride 
• 1563-43-5 5-(1-amino-ethylidene)-hept-3-ene-2,6-dione 
• 1721-13-7 ethyl 2,6-dimethylnicotinate 

Relevant articles and documents

Cu-Catalyzed Three-Component Cascade Annulation Reaction: An Entry to Functionalized Pyridines

A concise copper-catalyzed N-O bond cleavage/C-C/C-N bond formation procedure has been described for the synthesis of multisubstituted pyridines. Various oxime acetates, activated methylene compounds, and a wide range of aldehydes bearing aryl, heteroaryl, vinyl, and trifluoromethyl groups were employed to provide the tri- or tetrasubstituted pyridines with flexible substitution patterns. Moreover, this method features inexpensive catalysts, no need for extra oxidant, and high step-enconomy, which make it pratical and attractive.

One-step synthesis of thiazolo[3,2-a]pyridines by a multicomponent reaction of β-enaminonitriles, α,β-unsaturated aldehydes, and 2-aminothiol hydrochlorides

A wide library of 3,7,8,8a-tetrahydro-2H-thiazolo[3,2-a]pyridines has been prepared by simple heating in acetonitrile of β-enaminonitriles, α,β-unsaturated aldehydes and 2-aminothiol hydrochlorides. Chemical yields depend on the nature, hindrance, and position of the substituents. The scope, limitations, and stereocontrol associated to this three-component reaction have been studied in detail. In general, the diastereoinduction observed in the three new stereogenic centers generated in the pro-chiral α,β-unsaturated aldehyde is low.

Palladium-catalyzed regiocontrolled internal heteroarylation of electron-rich olefins with heteroaryl halides

A highly efficient palladium-catalyzed Heck coupling reaction of heteroaryl halides with electron-rich vinyl ether and hydroxyalkyl vinyl ethers is described. It was found that the choice of solvent, ligand, and reaction temperature had a fundamental influence on the regioselectivity and reactivity of the reaction, and the combination of Pd(OAc)2 and DPPF in ethylene glycol led to the most effective catalytic system. Under these conditions, a variety of heteroaryl halides reacted very quickly with electron-rich olefins to afford exclusively the branched products in good to excellent yields without employing triflates, halide scavengers, or ionic liquids.