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CAS

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344578-07-0

[[(2,2-Dimethoxy-ethyl)-ethoxycarbonyl-amino]-(2-methoxy-phenyl)-methyl]-phosphonic acid dimethyl ester is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 344578-07-0 Structure

  • Basic information

    1. Product Name: [[(2,2-Dimethoxy-ethyl)-ethoxycarbonyl-amino]-(2-methoxy-phenyl)-methyl]-phosphonic acid dimethyl ester
    2. Synonyms:
    3. CAS NO:344578-07-0
    4. Molecular Formula:
    5. Molecular Weight: 405.385
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 344578-07-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: [[(2,2-Dimethoxy-ethyl)-ethoxycarbonyl-amino]-(2-methoxy-phenyl)-methyl]-phosphonic acid dimethyl ester(CAS DataBase Reference)
    10. NIST Chemistry Reference: [[(2,2-Dimethoxy-ethyl)-ethoxycarbonyl-amino]-(2-methoxy-phenyl)-methyl]-phosphonic acid dimethyl ester(344578-07-0)
    11. EPA Substance Registry System: [[(2,2-Dimethoxy-ethyl)-ethoxycarbonyl-amino]-(2-methoxy-phenyl)-methyl]-phosphonic acid dimethyl ester(344578-07-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 344578-07-0(Hazardous Substances Data)

344578-07-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 344578-07-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,4,4,5,7 and 8 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 344578-07:
(8*3)+(7*4)+(6*4)+(5*5)+(4*7)+(3*8)+(2*0)+(1*7)=160
160 % 10 = 0
So 344578-07-0 is a valid CAS Registry Number.

344578-07-0Relevant articles and documents

Synthesis and radioligand binding studies of C-5- and C-8-substituted 1-(3,4-dimethoxybenzyl)-2,2-dimethyl-1,2,3,4-tetrahydroisoquinoliniums as SK channel blockers related to N-methyl-laudanosine and N-methyl-noscapine

Graulich, Amaury,Scuvée-Moreau, Jacqueline,Seutin, Vincent,Liégeois, Jean-Fran?ois

, p. 4972 - 4982 (2005)

The synthesis and the 125I-apamin binding studies of original C-5- and C-8-substituted 1-(3,4-dimethoxy-benzyl)-2,2-dimethyl-1,2,3,4- tetrahydroisoquinoliniums and 1-(3,4-dimethoxy-benzyl)-6,6-dimethyl-4,5,6,7- tetrahydrothieno[2,3-c]pyridiniums were performed in order to find a reversible and selective SK channel blocker structurally related to N-methyl-laudanosine and N-methyl-noscapine. A bulky alkyl substituent in the C-8 position of the tetrahydroisoquinoline produces a clear increase in the affinity for the apamin sensitive binding sites. The presence of an electron-withdrawing group in the C-5 and C-8 positions is not a suitable substitution for the affinity of drugs structurally related to N-methyl-laudanosine. Thiophenic analogues and 8-methoxy derivatives possess a poor affinity for the apamin sensitive binding sites. Electrophysiological studies performed with the most effective compound showed a blockade of the apamin sensitive afterhyperpolarization in rat dopaminergic neurons.

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