17266-98-7Relevant academic research and scientific papers
Palladium-catalyzed intramolecular nucleophilic substitution at the alkoxycarbonyl group
Sole, Daniel,Serrano, Olga
, p. 7270 - 7272 (2008/09/17)
(Chemical Equation Presented) Coaxed into action: Although ester groups are usually inert towards organopalladium reagents, β-(2-haloanilino)esters undergo intramolecular palladium-catalyzed acylation to give dihydroquinolin-4-ones (see scheme). A four-me
Structure-activity relationships of antimalarial indoloquinolines
Werbel, L. M.,Kesten, S. J.,Turner, W. R.
, p. 837 - 852 (2007/10/02)
Structure-activity relationships have been ascertained and chemical metodology developed for a series of antimalarial 3-chloroindoloquinoline-5-oxides.The basic side chain as well as the ring N-oxide are critical for antimalarial activity as is a bromine or chlorine in position 3.Substitution at positions 7,8,9,10 in not essential, although the most potent analog in our studies was the 8-nitro compound 4vv. indoloquinolines / antimalarial agents
