17290-70-9

Basic information

• Product Name: 6-Demethoxylnobiletin
• Synonyms: 6-Demethoxynobiletin;2-(3,4-Dimethoxyphenyl)-5,7,8-trimethoxy-4H-1-benzopyran-4-one;6-Demethoxylnobiletin;Isosinensetin;3',4' ,5,7,8-pentaMethoxyflavone;2-(3,4-Dimethoxyphenyl)-5,7,8-trimethoxy-4H-chromen-4-one;Isosinensetin3',4' ,5,7,8-pentamethoxyflavone
• CAS NO: 17290-70-9
• Molecular Formula: C₂₀H₂₀O₇
• Molecular Weight: 372.3686
• Mol File: 17290-70-9.mol
• Article Data: 5

Chemical Properties

• Melting Point: 198-199℃
• Boiling Point: 565.3±50.0 °C(Predicted)
• Appearance: /
• Density: 1.244±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 6-Demethoxylnobiletin(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Demethoxylnobiletin(17290-70-9)
• EPA Substance Registry System: 6-Demethoxylnobiletin(17290-70-9)

Safety Data

• Hazardous Substances Data: 17290-70-9(Hazardous Substances Data)

Usage

General Description

6-Demethoxylnobiletin is a flavonoid compound found in citrus fruits such as oranges and tangerines. It has been studied for its potential health benefits, including anti-inflammatory, anti-cancer, and neuroprotective properties. Research suggests that 6-Demethoxylnobiletin may have potential therapeutic effects in the treatment of various diseases, including cancer, cardiovascular disease, and neurodegenerative disorders, making it a promising candidate for further investigation and potential use in the development of new medications.

Upstream product

• 24824-54-2 3,4-dimethoxybenzoic anhydride 
• 4712-12-3 5,7-dihydroxy-3',4'-dimethoxy flavone 
• 480-66-0 2,4,6-trihydroxyacetophenone 
• 3535-37-3 3,4-dimethoxybenzoic acid chloride 
• 114866-06-7 2'-(3,4-dimethoxybenzoyloxy)-3',4',6'-trimethoxyacetophenone 
• 7507-98-4 1-(2-hydroxy-3,4,6-trimethoxyphenyl)ethanone 
• 832-58-6 1-(2,4,6-trimethoxyphenyl)ethanone 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 29080-58-8 5-hydroxy-3',4',7-trimethoxyflavone 
• 76650-20-9 1-(2,4,6-trimethoxyphenyl)-3-(3,4-dimethoxyphenyl)propenone 
• 114021-60-2 2'-hydroxy-3,4,4',6'-tetramethoxychalcone 
• 71847-58-0 5,8-dihydroxy-7-methoxy-2-(3,4-dimethoxyphenyl)-4-benzopyrone 
• 77-78-1 dimethyl sulfate 
• 7446-08-4 selenium(IV) oxide 

Downstream Products

• 18003-33-3 3',4',5,6,7-pentahydroxyflavone 
• 13003-74-2 5-hydroxy-3’,4’,7,8-tetramethoxyflavone 
• 27696-41-9 3′,4′,5,7,8-pentahydroxyflavone 

Relevant articles and documents

Miscrowave-assisted efficient synthesis of polymethoxyacetophenones and natural polymethoxyflavones, and thier inhibitory effects on melanogenesis

Microwave, assisted Friedel-Crafts acetylation of polymethoxybenzenes with acetic anhydride in the presence of In(CF3SO3)3 under solvent-free conditions was achieved rapidly to give polymethoxyacetophenones in high yields. Microwave-assisted benzoylation of 2'-hydroxypolymethoxyacetophenones with polymethoxybenzoyl chlorides, followed by the rearrangement of the resulting benzoates and the final formation of natural polymethoxyflavones was achieved rapidly and efficiently. The polymethoxyflavones showed inhibitory effects on melanogenesis in human melanoma cells.

Taste modifier and a method of modifying taste

Taste modifier comprising a flavone derivative as an active ingredient of the general formula (I): STR1 wherein R1, R3, R4, R6 and R8 are independently a methoxy group or an hydrogen atom, R2 and R7 are methoxy groups, and R5 is a methoxy group or an hydroxy group, and a method of modifying taste, comprising adding a taste-modifying effective amount of the flavone derivative (I) to a product used in a mouth or an orally ingestible product. Various factors associated with taste can be modified, for example, the derivative can enhance sourness, reduce saltiness, inhibit unpleasant lasting of sweetness, enhance refreshing flavor and its continuity, reduce flavor associated with acetic acid, and enhance body, deliciousness and savor associated with the combination of these tastes.

Flavanoids from Leaves of Callitris glauca R.Br. (Cupressaceae)

From the leaf extracts of Callitris glauca R.Br., a new glycoside, kaempferol-5-O-rhamnoside (I) has been isolated along with 3',4',5,7,8-pentahydroxyflavone (hypoletin), amentoflavone and sequoiaflavone.Di-O-methylamentoflavone and hinokiflavone have only been detected by TLC.