17290-70-9

Usage

Uses

Used in Pharmaceutical Industry:
6-Demethoxylnobiletin is used as a therapeutic agent for its anti-inflammatory properties, which can help in managing inflammation-related conditions. Its anti-cancer properties make it a candidate for the development of medications targeting various types of cancer, potentially enhancing the effectiveness of existing treatments or providing new avenues for cancer therapy.
Used in Cardiovascular Health Applications:
6-Demethoxylnobiletin is utilized as a cardioprotective agent due to its potential to mitigate the risks and effects of cardiovascular diseases. 6-Demethoxylnobiletin's ability to influence health outcomes in this area could lead to the creation of preventative or curative treatments for heart-related conditions.
Used in Neurodegenerative Disorder Treatment:
6-Demethoxylnobiletin is applied as a neuroprotective agent for its potential to shield the nervous system from degeneration. This use highlights its promise in the treatment or management of neurodegenerative disorders, offering hope for patients suffering from such conditions.
While the provided materials do not explicitly list the various industries in which 6-Demethoxylnobiletin could be applied, the above uses are inferred from its described properties and potential health benefits. Further research and development would be necessary to fully realize the compound's applications across different fields.

Upstream product

• 7446-08-4 selenium(IV) oxide 
• 71-41-0 pentan-1-ol 
• 91856-18-7 2'-hydroxy-3,4,3',4',6'-pentamethoxychalcone 
• 832-58-6 1-(2,4,6-trimethoxyphenyl)ethanone 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 29080-58-8 5-hydroxy-3',4',7-trimethoxyflavone 
• 76650-20-9 1-(2,4,6-trimethoxyphenyl)-3-(3,4-dimethoxyphenyl)propenone 
• 114021-60-2 2'-hydroxy-3,4,4',6'-tetramethoxychalcone 
• 71847-58-0 5,8-dihydroxy-7-methoxy-2-(3,4-dimethoxyphenyl)-4-benzopyrone 
• 77-78-1 dimethyl sulfate 
• 114866-05-6 1-(2-hydroxy-3,4,6-trimethoxyphenyl)-3-(3,4-dimethoxyphenyl)-1,3-propanedione 
• 27696-41-9 3′,4′,5,7,8-pentahydroxyflavone 
• 3535-37-3 3,4-dimethoxybenzoic acid chloride 
• 114866-06-7 2'-(3,4-dimethoxybenzoyloxy)-3',4',6'-trimethoxyacetophenone 

Downstream Products

• 27696-41-9 3′,4′,5,7,8-pentahydroxyflavone 
• 13003-74-2 5-hydroxy-3’,4’,7,8-tetramethoxyflavone 
• 18003-33-3 3',4',5,6,7-pentahydroxyflavone 

Relevant academic research and scientific papers

Miscrowave-assisted efficient synthesis of polymethoxyacetophenones and natural polymethoxyflavones, and thier inhibitory effects on melanogenesis

Microwave, assisted Friedel-Crafts acetylation of polymethoxybenzenes with acetic anhydride in the presence of In(CF3SO3)3 under solvent-free conditions was achieved rapidly to give polymethoxyacetophenones in high yields. Microwave-assisted benzoylation of 2'-hydroxypolymethoxyacetophenones with polymethoxybenzoyl chlorides, followed by the rearrangement of the resulting benzoates and the final formation of natural polymethoxyflavones was achieved rapidly and efficiently. The polymethoxyflavones showed inhibitory effects on melanogenesis in human melanoma cells.

Regioselective hydroxylation of 2-hydroxychalcones by dimethyldioxirane towards polymethoxylated flavonoids

The flavone nucleus is part of a large number of natural products and medicinal compounds. In this presentation the novel regioselective hydroxylation of hydroxyarenes with DMD is described. The results showed further that flavonoids with 5-hydroxy group were selectively oxyfunctionalized at the para-position C8 carbon atom by DMD. Finally, according to this methodology, the naturally occurring isosinensetin, tangeretin, sinensetin, nobiletin, natsudaidain, gardenin B, 3,3′,4′,5,6,7,8- heptamethoxyflavone, quercetin and its derivatives were synthesized.

Taste modifier and a method of modifying taste

Taste modifier comprising a flavone derivative as an active ingredient of the general formula (I): STR1 wherein R1, R3, R4, R6 and R8 are independently a methoxy group or an hydrogen atom, R2 and R7 are methoxy groups, and R5 is a methoxy group or an hydroxy group, and a method of modifying taste, comprising adding a taste-modifying effective amount of the flavone derivative (I) to a product used in a mouth or an orally ingestible product. Various factors associated with taste can be modified, for example, the derivative can enhance sourness, reduce saltiness, inhibit unpleasant lasting of sweetness, enhance refreshing flavor and its continuity, reduce flavor associated with acetic acid, and enhance body, deliciousness and savor associated with the combination of these tastes.

Syntheses of 6-Hydroxyluteolin and Sinensetin by Wessely - Moser Rearrangement

Syntheses of 6-hydroxyluteolin (1) and sinensetin (2) are described.The compounds 6 and 7 afford 1 on Wessely - Moser rearrangement.The synthetic samples 1 and 2 are identical (m.m.p. and co-ir) with the authentic samples.

Flavanoids from Leaves of Callitris glauca R.Br. (Cupressaceae)

From the leaf extracts of Callitris glauca R.Br., a new glycoside, kaempferol-5-O-rhamnoside (I) has been isolated along with 3',4',5,7,8-pentahydroxyflavone (hypoletin), amentoflavone and sequoiaflavone.Di-O-methylamentoflavone and hinokiflavone have only been detected by TLC.