173073-45-5Relevant academic research and scientific papers
LIPID-MODIFIED NUCLEIC ACID COMPOUNDS AND METHODS
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Paragraph 0555; 0557, (2019/12/25)
Disclosed herein, inter alia, are lipid-modified nucleic acid compounds of the following structure, their preparation, and their use: (I).
Bis-3-chloropiperidines containing bridging lysine linkers: Influence of side chain structure on DNA alkylating activity
Zuravka, Ivonne,Roesmann, Rolf,Sosic, Alice,G?ttlich, Richard,Gatto, Barbara
, p. 1241 - 1250 (2015/03/04)
A series of bis-3-chloropiperidines containing lysine linkers was synthesised as DNA alkylating model compounds by using a bidirectional synthetic strategy. These novel piperidine mustard based agents have been evaluated for their alkylating properties towards nucleic acids and were shown to alkylate and cleave DNA with strong preference for guanine residues. Our studies reveal that the introduction of aromatic groups in the side chain of the lysine linker has an impact on DNA alkylating activity. Analysis by ESI mass spectrometry enabled the verification of the reactive aziridinium ion formation. Overall, the results confirm our recently proposed reaction mechanism of bis-3-chloropiperidines.
Calixarene amino acids; building blocks for calixarene peptides and peptide-dendrimers
Hu, Heng,Kinsel, Gary R.,Zhang, Jiang,Li, Meiling,Rudkevich, Dmitry M.
, p. 5837 - 5848 (2007/10/03)
A modular strategy towards receptor macromolecules is presented, which combines synthetically diverse peptide synthesis with highly functional calixarene chemistry. The design and synthesis of calix[4]arene amino acids 1a-f, calix-lysines, is described, which were used as construction blocks to assemble nanoscale, multivalent entities - calix-peptides 2 and calix-peptide-dendrimers 3.
Aromatic derivatives with HIV integrase inhibitory properties
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, (2008/06/13)
A compound of formula I′ and pharmaceutically acceptable derivatives thereof including, for example, where applicable or appropriate pharmaceutically acceptable salts thereof. Ar and Ar′ are aromatic or aryl type groups. The compounds have HIV integrase inhibitory properties. Ar, Ar′ and W may be as defined in the specification.
