173199-86-5Relevant academic research and scientific papers
Sulfolene pyridinones as precursors for pyridinone ortho-quinodimethanes and their Diels-Alder adducts
Govaerts, Tom C,Vogels, Ilse,Compernolle, Frans,Hoornaert, Georges
, p. 799 - 802 (2007/10/03)
2(1H)-Pyrazinones were converted into [3,4-b] and [3,4-c] sulfolene pyridinones 4 and 5, serving as precursors for the corresponding 3,4- and 5,6-dimethylene 2(1H)-pyridinone ortho-quinodimethanes. These were trapped by in situ reaction with dienophiles. Tethering of 4 also enabled intramolecular cycloaddition.
Synthesis of a conformationally restricted dipeptide analogue and its evaluation as a β-turn mimic
De Borggraeve, Wim M.,Rombouts, Frederik J.R.,Van der Eycken, Erik V.,Toppet, Suzanne M.,Hoornaert, Georges J
, p. 5693 - 5695 (2007/10/03)
Dichloropyrazinone 3 was converted into a conformationally restricted dipeptide analogue 8 by means of a Diels-Alder strategy. The β-turn characteristics of molecule 8 were examined by molecular modeling and NMR spectroscopy.
Intramolecular Diels-Alder Reactions of 2(1H)-Pyrazinones: Synthesis of New Furo/Pyrano-pyridinones and -pyridines
Buysens, Kris J.,Vandenberghe, Didier M.,Toppet, Suzanne M.,Hoornaert, Georges J.
, p. 12463 - 12478 (2007/10/02)
2(1H)-Pyrazinones 2-5 with in 3-position either a 3- or 4-alkynyloxy side chain and 2(1H)-pyrazinones 9-10 carrying the corresponding 2- or 3-alkynyloxy(m)ethyl substituent are shown to undergo intramolecular Diels-Alder reaction.The formation of either f
