428506-72-3

Upstream product

• 173199-86-5 1-benzyl-5-chloro-3-methyl-2(1H)-pyrazinone 
• 87486-35-9 1-benzyl-3,5-dichloro-1H-pyrazin-2-one 
• 173199-90-1 1-benzyl-3-bromomethyl-5-chloro-2(1H)-pyrazinone 
• 507-09-5 tiolacetic acid 

Downstream Products

• 428506-74-5 1-benzyl-5-chloro-3-[(2-propynylsulfanyl)methyl]-2(1H)pyrazinone 
• 602327-76-4 N,N-diallyl-5-benzyl-1,3-dihydro-2,2,4-trioxo-5H-thieno[3,4-c]pyridin-3-carboxamide 
• 602327-71-9 N-allyl-2-(5-benzyl-1,3-dihydro-2,2,4-trioxo-H-thieno[3,4-c]pyridin-1-yl)-N-methylacetamide 
• 602327-73-1 5-(5-benzyl-1,3-dihydro-2,2,4-trioxo-5H-thieno[3,4-c]pyridin-3-yl)pentanenitrile 
• 602327-70-8 5-benzyl-1,3-dihydro-1-(4-pentenyl)-2,2-dioxothieno[3,4-c]pyridin-4(5H)-one 
• 602327-74-2 4-(5-benzyl-1,3-dihydro-2,2,4-trioxo-5H-thieno[3,4-c]pyridin-3-yl)butanenitrile 

Relevant academic research and scientific papers

Diels-Alder reactions of pyridinone o-quinodimethanes generated from substituted sulfolene[3,4-c]pyridin-4(1H)-ones

1-Benzyl-3-(bromomethyl)-2(1H)-pyrazinone was converted to [3,4-c] sulfolene pyridinone 8a and further (1- or 3-) substituted derivatives having a dienophilic side chain on the sulfolene ring. Thermolytic extrusion of sulfur dioxide from o-QDM precursor 8

Sulfolene pyridinones as precursors for pyridinone ortho-quinodimethanes and their Diels-Alder adducts

2(1H)-Pyrazinones were converted into [3,4-b] and [3,4-c] sulfolene pyridinones 4 and 5, serving as precursors for the corresponding 3,4- and 5,6-dimethylene 2(1H)-pyridinone ortho-quinodimethanes. These were trapped by in situ reaction with dienophiles. Tethering of 4 also enabled intramolecular cycloaddition.