17321-63-0

Basic information

• Product Name: 4-(Acetylamino)phenyl chloroacetate
• Synonyms: 4-(Acetylamino)phenyl chloroacetate;2-Chloroacetic acid 4-(acetylamino)phenyl ester;4-Acetamidophenol chloroacetate;4-AcetaMidophenyl 2-chloroacetate
• CAS NO: 17321-63-0
• Molecular Formula: C₁₀H₁₀ClNO₃
• Molecular Weight: 227.64
• Mol File: 17321-63-0.mol

Chemical Properties

• Melting Point: 184.75°C
• Appearance: /
• Density: 1.327
• Refractive Index: 1.5800 (estimate)
• Storage Temp.: 2-8°C
• Water Solubility: 0.28g/L(37 oC)
• CAS DataBase Reference: 4-(Acetylamino)phenyl chloroacetate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(Acetylamino)phenyl chloroacetate(17321-63-0)
• EPA Substance Registry System: 4-(Acetylamino)phenyl chloroacetate(17321-63-0)

Safety Data

• Hazardous Substances Data: 17321-63-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-(Acetylamino)phenyl chloroacetate is used as a precursor for the synthesis of various drugs. It plays a crucial role in the development of new pharmaceutical compounds, contributing to the advancement of medicine and healthcare.
Used in Dye Industry:
APAC is used as a reagent in the preparation of dyes. Its unique chemical properties allow for the creation of a wide range of dyes with different colors and properties, catering to various applications in the dye industry.
Used in Agrochemical Industry:
4-(Acetylamino)phenyl chloroacetate is employed in the manufacture of agrochemicals. Its use in this industry contributes to the development of effective and efficient agrochemical products, supporting agriculture and crop protection.
Safety Precautions:
It is important to handle and store 4-(Acetylamino)phenyl chloroacetate with care, as it is considered hazardous due to its potential to cause irritation and corrosion to skin and eyes. Proper safety measures should be taken during its use and storage to minimize any risks associated with its handling.

Upstream product

• 103-90-2 4-acetaminophenol 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 66532-85-2 Prodafalgan 
• 1234188-70-5 1-(2-(4-acetamidophenoxy)-2-oxoethyl)-1-methylpyrrolidiniuim chloride 
• 1234188-71-6 1-(2-(4-acetamidophenoxy)-2-oxoethyl)pyridinium chloride 
• 1234188-73-8 (2-(4-acetamidophenoxy)-2-oxoethyl)tributylphosphonium chloride 
• 1234188-69-2 1-(2-(4-acetamidophenoxy)-2-oxoethyl)-3-methyl-1H-imidazoI-3-ium chloride 
• 66532-86-3 2-(4-acetamidophenoxy)-N,N-diethyl-2-oxaethan-1-aminium chloride 
• 1234188-75-0 1-(2-(4-acetamidophenoxy)-2-oxoethyl)-3-methyl-1H-imidazol-3-ium docusate 
• 1234188-79-4 1-(2-(4-acetamidophenoxy)-2-oxoethyl)pyridinium docusate 
• 1234188-77-2 1-(2-(4-acetamidophenoxy)-2-oxoethyl)-1-methylpyrrolidinium docusate 

Relevant articles and documents

Acetaminophen prodrug: Microwave-assisted synthesis and in vitro metabolism evaluation by mass spectrometry

Propacetamol is an acetaminophen prodrug of intravenous administration used to control fever and pain of perioperative period in multimodal analgesia therapy. After injection, it is completely converted by plasma esterases into N,N-diethylglycine and acetaminophen, its active metabolite whose mechanism of action is the inhibition of prostaglandin synthesis. Herein, we report an improved protocol for the synthesis of propacetamol hydrochloride that allows the isolation of the active pharmaceutical ingredient (API) with high purity and yield. In addition, the in vitro metabolism of propacetamol in a microssomal reaction was evaluated by ion trap tandem mass spectrometry.

Propacetamol crystal form and preparation method thereof

The invention discloses a propacetamol crystal form and a preparation method thereof, and relates to the technical field of chemical organic synthesis. Acetaminophen and chloroacetyl chloride are usedas starting materials, the propacetamol crystal form is prepared through a chloroacetylation reaction and an ammoniation reaction, and the propacetamol crystal form is not reported in the prior art Propacetamol solid is prepared by utilizing the preparation method, and therefore, the feeding amount can be accurately controlled when the propacetamol hydrochloride is prepared through a subsequent salt forming reaction, the situation that the dosage of hydrochloric acid is too large or too small is avoided, and the problem that in the prior art, the yield and purity of the product propacetamol hydrochloride are seriously affected when the propacetamol hydrochloride is prepared through a propacetamol oily matter is solved.

Improved propacetamol hydrochloride preparation process

The invention belongs to the field of synthesis of organic matters with carbon rings and provides an improved propacetamol hydrochloride preparation process. The process comprises: 1) carrying out acylation reaction to synthesize 4-acetamido phenol chlora

DUAL FUNCTIONING IONIC LIQUIDS AND SALTS THEREOF

Disclosed herein are ionic liquid compositions comprising active pharmaceutical, biological, and nutritional compounds, and methods of use. Further disclosed are compositions of matter including liquid ion pairs alone or in solution and their use; compositions of ionic liquids that are 'solvated,' for example, 'hydrated' and their uses.