17321-63-0

Basic information

• Product Name: 4-(Acetylamino)phenyl chloroacetate
• Synonyms: 4-(Acetylamino)phenyl chloroacetate;2-Chloroacetic acid 4-(acetylamino)phenyl ester;4-Acetamidophenol chloroacetate;4-AcetaMidophenyl 2-chloroacetate
• CAS NO: 17321-63-0
• Molecular Formula: C₁₀H₁₀ClNO₃
• Molecular Weight: 227.64
• Mol File: 17321-63-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 184.75°C
• Appearance: /
• Density: 1.327
• Refractive Index: 1.5800 (estimate)
• Storage Temp.: 2-8°C
• Water Solubility: 0.28g/L(37 oC)
• CAS DataBase Reference: 4-(Acetylamino)phenyl chloroacetate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(Acetylamino)phenyl chloroacetate(17321-63-0)
• EPA Substance Registry System: 4-(Acetylamino)phenyl chloroacetate(17321-63-0)

Safety Data

• Hazardous Substances Data: 17321-63-0(Hazardous Substances Data)

Usage

General Description

4-(Acetylamino)phenyl chloroacetate, also known as APAC, is a chemical compound with the molecular formula C10H10ClNO3. It is an ester formed by the condensation of chloroacetic acid and 4-(acetylamino)phenol. APAC is commonly used as a reagent in organic synthesis, particularly in the preparation of pharmaceutical compounds and dyes. It is a white to off-white crystalline solid with a melting point of 67-69°C and is soluble in organic solvents such as ethanol and acetone. APAC is used as a precursor for the synthesis of various drugs and is also employed in the manufacture of agrochemicals. It is important to handle and store APAC with care, as it is considered hazardous due to its potential to cause irritation and corrosion to skin and eyes.

Upstream product

• 103-90-2 4-acetaminophenol 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 1234188-70-5 1-(2-(4-acetamidophenoxy)-2-oxoethyl)-1-methylpyrrolidiniuim chloride 
• 1234188-71-6 1-(2-(4-acetamidophenoxy)-2-oxoethyl)pyridinium chloride 
• 1234188-73-8 (2-(4-acetamidophenoxy)-2-oxoethyl)tributylphosphonium chloride 
• 1234188-69-2 1-(2-(4-acetamidophenoxy)-2-oxoethyl)-3-methyl-1H-imidazoI-3-ium chloride 
• 66532-85-2 Prodafalgan 
• 66532-86-3 2-(4-acetamidophenoxy)-N,N-diethyl-2-oxaethan-1-aminium chloride 
• 1234188-75-0 1-(2-(4-acetamidophenoxy)-2-oxoethyl)-3-methyl-1H-imidazol-3-ium docusate 
• 1234188-79-4 1-(2-(4-acetamidophenoxy)-2-oxoethyl)pyridinium docusate 
• 1234188-77-2 1-(2-(4-acetamidophenoxy)-2-oxoethyl)-1-methylpyrrolidinium docusate 

Relevant articles and documents

Acetaminophen prodrug: Microwave-assisted synthesis and in vitro metabolism evaluation by mass spectrometry

Propacetamol is an acetaminophen prodrug of intravenous administration used to control fever and pain of perioperative period in multimodal analgesia therapy. After injection, it is completely converted by plasma esterases into N,N-diethylglycine and acetaminophen, its active metabolite whose mechanism of action is the inhibition of prostaglandin synthesis. Herein, we report an improved protocol for the synthesis of propacetamol hydrochloride that allows the isolation of the active pharmaceutical ingredient (API) with high purity and yield. In addition, the in vitro metabolism of propacetamol in a microssomal reaction was evaluated by ion trap tandem mass spectrometry.

Improved propacetamol hydrochloride preparation process

The invention belongs to the field of synthesis of organic matters with carbon rings and provides an improved propacetamol hydrochloride preparation process. The process comprises: 1) carrying out acylation reaction to synthesize 4-acetamido phenol chlora

Acetaminophen prodrugs. I. Synthesis, physicochemical properties, and analgesic activity.

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