173259-96-6

Upstream product

• 88075-87-0 2-Cyano-3-methylthio-3-(2-thienyl)acrylonitrile 
• 28162-32-5 2-(2-thienyl)-1-cyanoacrylonitrile 
• 100-63-0 phenylhydrazine 
• 98-03-3 thiophene-2-carbaldehyde 
• 109-77-3 malononitrile 

Downstream Products

• 173260-07-6 dimethyl 4-amino-1-phenyl-3-(thiophen-2-yl)pyrazolo[3,4-b]pyridine-5,6-dicarboxylate 

Relevant academic research and scientific papers

One-pot and efficient synthesis of 5-aminopyrazole-4-carbonitriles catalyzed by potassium phthalimide

The potassium phthalimide (PPI) has been found to be an efficient, recyclable, inexpensive, commercially available, and easy to handle catalyst for the synthesis of 5-aminopyrazole-4-carbonitriles through the one-pot, three-component reaction of easily av

CuCl3: As an efficient catalyst for the preparation of 5-amino-1H-pyrazole-4-carbonitriles by anomeric based oxidation

3-Methyl-1-sulfonic acid imidazolium trichlorido copper (II) {[Msim]CuCl3} was prepared and used as a new catalyst for the preparation of 5-amino-1H-pyrazole-4-carbonitriles. In this reaction, the pyrazole ring was formed by an anomeric and vinylogous ano

Core-shell structured magnetite silica-supported hexatungstate: A novel and powerful nanocatalyst for the synthesis of biologically active pyrazole derivatives

This article describes the synthesis of a novel core-shell structured magnetic silica-supported hexatungstate (Fe3O4@SiO2-NH3[W6O19]) nanocatalyst through immobilization of hexatungstate on

Superparamagnetic Fe3O4@Alginate supported L-arginine as a powerful hybrid inorganic–organic nanocatalyst for the one-pot synthesis of pyrazole derivatives

Hybrid inorganic–organic material Fe3O4@Alg@CPTMS@Arg, was prepared by the layer-by-layer techniques through grafting l-arginine (l-arg) to Fe3O4@Alg using 3-chloropropyltrimethoxysilane (CPTMS) as a linker. Fe

Sodium ascorbate as an expedient catalyst for green synthesis of polysubstituted 5-aminopyrazole-4-carbonitriles and 6-amino-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles

Sodium ascorbate (SA) was used as a safe catalyst for the synthesis of 5-aminopyrazole-4-carbonitriles from the one-pot three-component cyclocondensation (3-CC) of aldehydes, phenylhydrazine, and malononitrile at 50?°C. This 3-CC proceeds in a mixture of

Glucose-coated superparamagnetic nanoparticle-catalysed pyrazole synthesis in water

A green, benign, heterogeneous, superparamagnetic catalyst (Glu.@Fe3O4) was synthesized and characterized using Fourier transform infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, scanning electron microscopy and vibrating sample magnetometry. The prepared catalyst was used to achieve a high-efficiency, low-cost, eco-friendly and easy-to-handle protocol for synthesizing substituted pyrazole derivatives from aldehydes, malononitrile and phenylhydrazine. The catalyst was also used in chromene synthesis. Glucose coated on magnetic nanoparticles provided excellent catalytic activity. The catalyst could be recycled for up to four runs without significant loss in catalytic activity.

Synthesis of pyrazole derivatives in the presence of a dioxomolybdenum complex supported on silica-coated magnetite nanoparticles as an efficient and easily recyclable catalyst

Efficient synthesis of pyrazole derivatives catalyzed by a dioxomolybdenum complex supported on functionalized Fe3O4 magnetite nanoparticles containing a Schiff base ligand is reported. The synthesized catalyst was characterized by X

An environmental friendly approach for the catalyst-free synthesis of highly substituted pyrazoles promoted by ultrasonic radiation

A cost-effective, highly useful and eco-friendly procedure for the one-pot synthesis of highly substituted pyrazole derivatives has been developed via the reaction of various aldehydes, malononitrile and phenylhydrazine or 4-phenylthiosemicarbazide in PEG

Method of quantitative determination of peroxide, a peroxidation-active substance or a pyrazolopyridopyridazine derivative

Disclosed is a chemiluminescent method of quantitatively determining one of peroxide, a peroxidation-active substance or a pyrazolopyridopyridazine derivative represented by the formula (I): wherein R1represents hydrogen, lower alkyl, optionally substituted aryl, optionally substituted heterocyclic group, substituted sulfonyl, substituted sulfinyl, substituted thio etc.; R2represents hydrogen, lower alkyl, optionally substituted aryl, etc., or a salt thereof;, characterized by subjecting an unknown amount of one substance selected from the peroxide, peroxidation-active substance and pyrazolopyridopyridazine derivative to react with a known amount of the remaining two substances.

Synthesis and chemiluminescence of 1,3-disubstituted pyrazolo[4',3':5,6]pyrido[2,3-d]pyridazine-5,8(6H,7H)-diones and related compounds

Reactions of 1,3-disubstituted 5-aminopyrazole 5-aminopyrazole-4-carbonitrile derivatives (3a-o) with dimethyl acetylenedicarboxylate in the presence of potassium carbonate in dimethyl sulfoxide gave the corresponding dimethyl 1,3-disubstituted pyrazolo[3,4-b]pyridine-5,6-dicarboxylates (4a-o) which were allowed to react with excess hydrazine hydrate in ethanol under reflux followed by heating at 250-300°C to give 1,3-disubstituted 4-amino-1H-pyrazolo[4',3':5,6]pyrido[2,3-d]pyridazine-5,8(6H,7H)-dione s (7a-s) in good yields. These tricyclic pyridazine derivatives were evaluated for chemiluminescence. Some were found to be more efficient than luminol in light production. 4-Amino-3-methylsulfonyl-1-phenyl-1H-pyrazolo[4',3':5,6]pyrido[2,3-d]p yridazine-5,8(6H,7H)-dione (7r) showed the greatest chemiluminescence intensity derivatives in the presence of H2O2, peroxidase, in a solution of phosphate buffer pH 8.0.