19093-67-5Relevant academic research and scientific papers
PEGylated dendrimer polystyrene support: Synthesis, characterisation and evaluation of biologically active peptides
Siyad,Vinod Kumar
, p. 947 - 959 (2013)
Poly(N,N-bisethylamine) dendrimers with high content of poly(ethylene glycol) were synthesized on 3-(Acryloyloxy)-2-hydroxypropylmethacrylate- crosslinked polystyrene (PS-AHMA) resin and tested in various conditions of solid phase peptide synthesis. The d
Poly(ethylene glycol) grafted polystyrene dendrimer resins: Novel class of supports for solid phase peptide synthesis
Siyad,Kumar, G.S. Vinod
, p. 4076 - 4090 (2012)
Poly(propyleneglycol)dimethacrylate cross-linked support using monomers Styrene and 4-chloromethyl styrene (PS-PPGDMA-VBC resin) was prepared by suspension polymerization method. Dendritic templates were synthesized from Schiff base and trimesic acid molecules and assembled independently on PS-PPGDMA-VBC support to the second generation. N,N-bischloro ethyl amine dendrimer was generated from Schiff base units and introduced to the chloromethyl groups uniquely through secondary amine. It was followed by acidolytic cleavage, diazotization and thionyl chloride reactions leading to first generation dendrimer. O-benzyl ether dendrimer was created using 1,3,5-tris(hydroxyl methyl)benzene unit which was produced by the LiAlH 4 reduction of carbonyl groups of trimesic acid molecule. The hydroxyl methyl groups formed were converted to chloro methyl groups by adding thionyl chloride that leads to first generation dendrimer. Similar synthetic routes were followed to produce second generation dendrimers too. Poly(ethylene glycol), Mn ≈ 1500) has been grafted to chlorine termini of both dendrimers and used to check various physical and chemical properties of different peptide synthetic conditions. Reactions were qualitatively analyzed by FTIR, 13C NMR, SEM and quantitatively analyzed by UV measurements and CHN analysis. Classically difficult ACP sequence was synthesized on both PEGylated dendrimer supports and compared to Tenta Gel. Biologically significant disulfide bonded endothelin class of peptides were also synthesized using novel supports using various literature reported methods.
Synthetic evaluation of disulphide-bonded sarafotoxin on a poly(oxy ether) grafted dendrimeric poly(alkyl amine) support for polymer assisted organic synthesis
Siyad,Kumar, G. S. Vinod
, p. 4860 - 4870 (2013)
The present paper describes the synthesis, characterization and assessment of a novel class of insoluble polymeric polystyrene supports which combines polar poly(ethylene glycol)dimethacrylate as a cross-linker and poly(ethylene glycol) grafted poly(N,N-b
High-denticity ligands based on picolinic acid for 111In radiochemistry
Price, Eric W.,Ferreira, Cara L.,Adam, Michael J.,Orvig, Chris
, p. 695 - 705 (2014/08/18)
Four new acyclic ligands, Bn-H3nonapa (3), H3nonapa (4), p-NO2-Bn-H3nonapa (10), and Bn-H3trenpa (7), were synthesized and studied with nonradioactive In3+ and with radioactive 111/su
A class of linker free amphiphilic PEG grafted polymer support for linear and cyclic peptides
Siyad,Vinod Kumar
, p. 60404 - 60408 (2015/02/19)
PEG grafted (PEG400 and PEG1500), highly hydrophobic/hydrophilic balanced polymeric Schiff base dendron resins were synthesized by the reaction between diethylenetriamine and benzaldehyde molecules and characterized. The usefulness o
BIFUNCTIONAL CHELATING AGENTS
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Page/Page column 108, (2011/09/19)
A bifunctional chelating agent of the formula (I): wherein the variables R1, R1 , Q1, Q2 and M are as defined in the description of the present application. Also described is a complex of the above chelating age
STRAIGHT-CHAIN AND BRANCHED-CHAIN LIPID COMPOUNDS AS SELECTIVE INHIBITORS OF CYCLOOXYGENASE-2, ANTI-INFLAMMATORY AGENTS, AND ANTI-CANCER AGENTS
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Page/Page column 9-11, (2008/06/13)
Unique branched-chain lipid compounds are disclosed as selective COX-2 inhibitors, which are derivatives of a branched-chain fatty amine or a branched-chain fatty amide, or a pharmaceutically acceptable salt thereof. The compounds can be used for osteoarthritis and rheumatoid arthritis as anti-inflammatory agents, in addition to treating and preventing cancer. Straight-chain analogs of the branched-chain lipid compounds provide similar uses.
Concerning two-metal cooperativity in model phosphate hydrolysis
Leivers, Martin,Breslow, Ronald
, p. 345 - 356 (2007/10/03)
Three series of bimetallic ligands were tested for cooperativity in the hydrolysis of phosphate esters. It was shown that rate enhancements were in part contributed by binding to the hydrophobic linkers when the substrates were also hydrophobic, and two metal cooperativity was not found to be present. Kinetic order tests were performed and shown to be superior to previous methods for analyzing cooperativity.
