1734-62-9

Basic information

• Product Name: LR-70
• Synonyms: 2-Acetyloxy-5-chlorobenzoic acid;5-Chloro-2-acetoxybenzoic acid;LR-70;2-(acetyloxy)-5-chlorobenzoic acid(SALTDATA: FREE)
• CAS NO: 1734-62-9
• Molecular Formula: C₉H₇ClO₄
• Molecular Weight: 214.6
• Mol File: 1734-62-9.mol
• Article Data: 24

Chemical Properties

• Melting Point: 148 °C
• Boiling Point: 348.7°C at 760 mmHg
• Flash Point: 164.7°C
• Appearance: /
• Density: 1.416g/cm³
• Vapor Pressure: 1.86E-05mmHg at 25°C
• Refractive Index: 1.565
• PKA: 3.11±0.10(Predicted)
• CAS DataBase Reference: LR-70(CAS DataBase Reference)
• NIST Chemistry Reference: LR-70(1734-62-9)
• EPA Substance Registry System: LR-70(1734-62-9)

Safety Data

• Hazard Codes: Xn
• Statements: 22-41-43
• Safety Statements: 26-36/37-39
• Hazardous Substances Data: 1734-62-9(Hazardous Substances Data)

Usage

General Description

LR-70 is a chemical compound used as a rocket propellant. It is a mixture of 73% HMX (high-melting explosive), 15% of aluminum powder, and 12% of solid polybutadiene. LR-70 is known for its high energy content and is often used in solid rocket motors for military and aerospace applications. The combination of HMX and aluminum powder provides a powerful and efficient combustion process, while the solid polybutadiene acts as a binding agent to hold the mixture together. LR-70 is highly stable and has a long shelf life, making it a popular choice for solid rocket propulsion systems.

InChI:InChI=1/C9H7ClO4/c1-5(11)14-8-3-2-6(10)4-7(8)9(12)13/h2-4H,1H3,(H,12,13)

Upstream product

• 321-14-2 5-chloro-2-hydroxybenzoic acid 
• 108-24-7 acetic anhydride 
• 75-36-5 acetyl chloride 

Downstream Products

• 5538-53-4 2-acetoxy-5-chlorobenzoyl chloride 
• 2497-02-1 N-acetyl-L-histidine 
• 1188-37-0 N-acetyl-(S)-glutamic acid 
• 997-55-7 N-Acetyl-L-aspartic acid 
• 97-69-8 (S)-acetamidoalanine 
• 543-24-8 N-acetylglycine 

Relevant articles and documents

Synthesis and molecular docking based exploration of salicylic acid derivatives

In present study, four salicylic acid derivatives viz., 2-acetoxybenzoic acid (2a), 2-(1H-indol-2-yl)benzoic acid (3a), 5-chloro-2-acetoxybenzoic acid (2b) and 5-chloro-2-(1H-indol-2-yl)benzoic acid (3b) were synthesized and studied for molecular docking on 3JUS and 3UPI protein selected from pdb. The studies show that all of the four synthesized compounds were found to be docked. Compound 3a and 3b showed the best ligand pose energy -10.8163 kcal/mol and -11.1354 kcal/mol with docking run: elapsed time 9 s and 12 s, respectively in respect of 3JUS Further, compounds 3a and 3b showed the best ligand pose energy -9.17851 and -9.54722 kcal/mol with docking run: elapsed time 10 and 14 s, respectively in case of 3UPI. Hence, studies showed that 5-chloro-2-(1H-indol-2-yl)benzoic acid (3b) emerged as potent compound which might show diverse nature of biological and therapeutic activity.

Synthesis and biological evaluation of novel N-substituted benzamides as anti-migration agents for treatment of osteosarcoma

A novel series of novel N-substituted (indole or indazole) benzamides were synthesized, and their anti-tumor properties were evaluated. The majority of tested compounds possessed moderate cytotoxicity, but inspiringly, we verified that active compound 5d presents an astonishing advantage by inhibiting the adhesion, migration, and invasion of osteosarcoma (OS) cells in vitro. Mechanistically, we confirmed 5d inhibited the migration ability of OS cells via the expression of genes related to adhesion, migration, and invasion. This effects of 5d suggest that it can be used as a potential chemotherapeutic drug to some aggressive and/or metastatic cancers, as well as in combination with other clinical anti-cancer drugs. In turn, this could enhance the therapeutic effect or reduce the risk of cell migration.

Development of 5-nitrothiazole derivatives: Identification of leads against both replicative and latent Mycobacterium tuberculosis

Twenty eight 5-nitrothiazole derivatives were synthesized and evaluated for in vitro activities against Mycobacterium tuberculosis (MTB), cytotoxicity against HEK 293T. Among the compounds, 5-nitro-N-(5-nitrothiazol-2-yl)furan-2- carboxamide (20) was found to be the most active compound in vitro with MICs of 5.48 μM against log-phase culture of MTB and also non-toxic up to 100 μM.