17343-54-3

Usage

Uses

Used in Pharmaceutical Industry:
(S)-Benzyl 1-cyanoethylcarbaMate is used as a building block for the synthesis of various pharmaceuticals. Its unique structure allows for the creation of a wide range of medicinal compounds, making it an essential component in drug development.
Used in Agrochemical Industry:
In the agrochemical sector, (S)-benzyl 1-cyanoethylcarbaMate is utilized as a key component in the production of various agrochemicals. Its reactivity and structural properties enable the synthesis of effective compounds for agricultural applications.
Used in Chiral Drug Production:
(S)-Benzyl 1-cyanoethylcarbaMate has potential applications in the production of chiral drugs. Its unique properties make it a valuable starting material for the synthesis of complex organic compounds, particularly those with chiral centers that are crucial for the efficacy and selectivity of certain medications.
Used in Organic Synthesis:
As a building block in organic synthesis, (S)-benzyl 1-cyanoethylcarbaMate is employed for the development of new materials and chemical processes. Its reactivity and structural characteristics facilitate the creation of a diverse array of organic compounds for various applications across different industries.

Upstream product

• 13139-27-0 L-α-N-Cbz-alaninamide 
• 65638-93-9 N-Carbobenzoxy-L-alanin-kohlensaeureaethylesteranhydrid 
• 28819-05-8 (S)-2-benzyloxycarbonylamino-propionic acid methyl ester 
• 501-53-1 benzyl chloroformate 
• 1142-20-7 N-Cbz-Ala 

Downstream Products

• 141041-83-0 N-(Benzyloxycarbonyl)-DL-thioalaninamid 
• 140903-18-0 (S)-2-Benzyloxycarbonylamino-thiopropionimidic acid ethyl ester; hydrochloride 
• 13139-29-2 2-benzyloxycarbonylamino-(S)-propioimino ethyl ether 
• 33876-18-5 benzyl N-[(1S)-1-(1H-1,2,3,4-tetrazol-5-yl)ethyl]carbamate 
• 944913-86-4 (S)-2-(N-benzyl-N-benzyloxycarbonylamino)-propionitrile 
• 33876-18-5 C₁₁H₁₃N₅O₂ 
• 140903-28-2 N-(Benzyloxycarbonyl)-L-dithioalanin-methylester 
• 141041-84-1 N-(Benzyloxycarbonyl)-DL-dithioalanin-methylester 
• 140903-28-2 2-Benzyloxycarbonylamino-dithiopropionic acid methyl ester 
• 141041-81-8 N-(Benzyloxycarbonyl)-L-dithioalanin-ethylester 
• 140903-23-7 N-(Benzyloxycarbonyl)-D-dithioalanin-ethylester 
• 17337-88-1 (R)-2-((S)-1-benzyloxycarbonylamino-ethyl)-4,5-dihydro-thiazole-4-carboxylic acid ethyl ester 
• 17337-89-2 [1-(4-carbamoyl-4,5-dihydro-thiazol-2-yl)-ethyl]-carbamic acid benzyl ester 
• 400652-46-2 ((S)-2-amino-1-methyl-ethyl)-carbamic acid benzyl ester 

Relevant academic research and scientific papers

Dehydration of Chiral α-Amides to Chiral α-Nitriles Under the Appel Reaction Conditions

An efficient synthesis of Nα-protected amino nitriles from Nα-protected amino acid amides employing Ph3P, I2 and NMM was described. Various amino acid amides, protected by Fmoc, Z and Boc were conveniently conve

C-terminal 1-aminoethyltetrazole-containing oligopeptides as novel alanine racemase inhibitors

In clinical culture media inoculated with patient samples, selective inhibition of commensal bacteria is essential for accurate diagnosis and effective treatment, as they can mask the presence of pathogenic bacteria. The alanine analogue, 1-aminoethyltetr

ANTIBACTERIAL COMPOUND AND USES OF SAME

A new compound exhibiting particularly advantageous antibacterial properties, and having the structural formula: L-pyroglutamyl-L-1-aminoethyltetrazole (or N-(1-(1H-tetrazol-5-yl)ethyl)-5-oxopyrrolidine-2-carboxamide). Also, the use of this compound in mi

Acceptor-Controlled Transfer Dehydration of Amides to Nitriles

Palladium-catalyzed dehydration of primary amides to nitriles efficiently proceeds under mild, aqueous conditions via the use of dichloroacetonitrile as a water acceptor. A key to the design of this transfer dehydration catalysis is the identification of an efficient water acceptor, dichloroacetonitrile, that preferentially reacts with amides over other polar functional groups with the aid of the Pd catalyst and makes the desired scheme exergonic, thereby driving the dehydration.

CATHEPSIN CYSTEINE PROTEASE INHIBITORS

This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.

CATHEPSIN CYSTEINE PROTEASE INHIBITORS

This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.

CATHEPSIN CYSTEINE PROTEASE INHIBITORS

This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is i

One-pot synthesis of orthogonally protected dipeptide selenazoles employing Nα-amino selenocarboxamides and α-bromomethyl ketones

A simple and efficient protocol for the synthesis of selenazole containing dipeptidomimetics using Nα-amino selenocarboxamides and α-bromomethyl ketones is described. All the compounds made were isolated in good yields and fully characterized.

Discovery, biological evaluation, and structure-activity relationship of amidine based sphingosine kinase inhibitors

Sphingosine 1-phosphate (S1P), a potent phospholipid growth and trophic factor, is synthesized in vivo by two sphingosine kinases. Thus these kinases have been proposed as important drug targets for treatment of hyperproliferative diseases and inflammation. We report here a new class of amidine-based sphingosine analogues that are competitive inhibitors of sphingosine kinases exhibiting varying degrees of enzyme selectivity. These inhibitors display KI values in the submicromolar range for both sphingosine kinases and, in cultured vascular smooth muscle cells, decrease S1P levels and initiate growth arrest.

AmIno Acid Homologation by the Blaise Reaction: A new entry into nitrogen heterocycles

(Chemical Equation Presented) A general strategy for the amino acid homologation via Blaise reaction and subsequent reduction is presented. This strategy involves the preparation of protected α-amino nitriles from the corresponding amino acids, followed by the zinc-mediated condensation of tert-butyl bromoacetate, to give the imidazolidones after iminozincate cyclization. Reduction gave the saturated imidazolidinones with cis or trans stereochemistry, depending on the reduction conditions. This strategy was applied to nonfunctionalized amino acids and to functionalized amino acids such as serine and aspartic acid. Additionally, acidic hydrolysis of cis or trans imidazolidinones to the corresponding chiral 4-aminopyrrolidones is described.