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1735-89-3

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1735-89-3 Usage

Uses

6-(Trifluoromethyl)indolin-2-one is used in preparation of oxindole derivatives as neuronal death inhibitors.

Check Digit Verification of cas no

The CAS Registry Mumber 1735-89-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,7,3 and 5 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1735-89:
(6*1)+(5*7)+(4*3)+(3*5)+(2*8)+(1*9)=93
93 % 10 = 3
So 1735-89-3 is a valid CAS Registry Number.
InChI:InChI=1/C9H6F3NO/c10-9(11,12)6-2-1-5-3-8(14)13-7(5)4-6/h1-2,4H,3H2,(H,13,14)

1735-89-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-TRIFLUOROMETHYLOXINDOLE

1.2 Other means of identification

Product number -
Other names 6-Trifluoromethyl oxindole

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1735-89-3 SDS

1735-89-3Relevant articles and documents

A safe and selective method for reduction of 2-nitrophenylacetic acid systems to N-aryl hydroxamic acids using continuous flow hydrogenation

Ichire, Ogar,Jans, Petra,Parfenov, Galina,Dounay, Amy B.

, p. 582 - 585 (2017/01/16)

The cyclic hydroxamic acid functional group is critical to the biological activity of numerous natural products and drug candidates. Efficient, reliable, and green synthetic methods to produce cyclic hydroxamic acids are needed. Herein, flow hydrogenation has been explored as a novel approach toward achieving the selective partial reduction of 2-nitrophenylacetic acid to 1-hydroxyindolin-2-one. The bidentate ligand, 1,10-phenanthroline, has been identified as a unique inhibitor for modulating product selectivity in this Pt/C-catalyzed process. Under the newly optimized reaction conditions, the targeted hydroxamic acid is produced with high selectivity (49:1) over the lactam by-product. The scope of the reaction is demonstrated for a variety of 2-nitrophenylacetic acid derivatives.

SYNTHESIS OF THROMBOPOIETIN ACTIVITY MODULATING COMPOUNDS

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Page/Page column 49-50, (2008/06/13)

Disclosed herein are various methods for synthesizing compounds that modulate thrombopoietin activity. Also disclosed are intermediates useful for the preparation of these compounds.

3-(PIPERAZINYLBENZYLIDENYL)-2-INDOLINONE COMPOUNDS AND DERIVATIVES AS PROTEIN TYROSINE KINASE INHIBITORS

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, (2008/06/13)

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