865080-02-0Relevant articles and documents
Synthesis of spirooxindoles via asymmetric 1,3-dipolar cycloaddition
Ding, Ke,Wang, Guoping,Deschamps, Jeffrey R.,Parrish, Damon A.,Wang, Shaomeng
, p. 5949 - 5951 (2007/10/03)
An efficient method was developed for the asymmetric synthesis of 2′-alkyl-4′aryl-1H-spiro[indole-3,3′-pyrrolidin]-2-ones, which are potential inhibitors of the p53-MDM2 interaction. Our X-ray crystallographic analysis revealed that this 1,3-dipolar cycloaddition proceeds with high stereoselectivity but differently from previously published results.