1736-66-9

Usage

Uses

Used in Organic Synthesis:
N-(2,2-Difluoro-6-nitro-benzo[1,3]dioxol-5-yl)acetamide is used as a synthetic intermediate for the development of various organic compounds. Its unique structure, featuring a difluoro and nitro group attached to a benzo[1,3]dioxole ring, allows it to participate in a range of chemical reactions, facilitating the synthesis of target molecules with specific properties.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, N-(2,2-Difluoro-6-nitro-benzo[1,3]dioxol-5-yl)acetamide is utilized as a building block in the synthesis of potential drug candidates. Its chemical properties and reactivity make it suitable for the creation of new molecules with therapeutic potential, contributing to the discovery and development of novel medications.
Used in Chemical Research:
N-(2,2-Difluoro-6-nitro-benzo[1,3]dioxol-5-yl)acetamide also finds application in chemical research, where it can be employed to study reaction mechanisms, explore new synthetic routes, and investigate the properties of related compounds. Its use in research aids in advancing the understanding of organic chemistry and contributes to the broader scientific knowledge base.

InChI:InChI=1/C9H6F2N2O5/c1-4(14)12-5-2-7-8(3-6(5)13(15)16)18-9(10,11)17-7/h2-3H,1H3,(H,12,14)

Upstream product

• 1544-85-0 2,2-difluoro-benzo[1,3]dioxol-5-ylamine 
• 948-94-7 N-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)acetamide 

Downstream Products

• 1644-86-6 2,2-difluoro-6-nitrobenzo[d][1,3]dioxol-5-amine 
• 1744-12-3 2,2-difluorobenzo[d][1,3]dioxole-5,6-diamine 

Relevant academic research and scientific papers

BENZIMIDAZOLE COMPOUND HAVING AN OPTIONALLY HALOGENATED ALKYLENEDIOXY GROUP OR SALT THEREOF, AGRICULTURAL AND HORTICULTURAL INSECTICIDE COMPRISING THE COMPOUND OR THE SALT, AND METHOD FOR USING THE INSECTICIDE

Provided are a benzimidazole compound represented by the general formula (1) {wherein R1 represents a hydrogen atom or a cyano group, R2 represents a (C1-C6) alkyl group, a (C1-C6) alkoxy (C1-C6) alkyl group, or a halo (C1-C6) alkyl group, R represents a (C1-C3) alkylene group or a halo (C1-C3) alkylene group, and m represents 0, 1, or 2}, or a salt thereof, an agricultural and horticultural insecticide comprising the compound or the salt as an active ingredient; an animal ectoparasite or endoparasite control agent comprising the compound or the salt as an active ingredient; and a method for using the insecticide or the agent.

BIFLUORODIOXALANE-AMINO-BENZIMIDAZOLE KINASE INHIBITORS FOR THE TREATMENT OF CANCER, AUTOIMMUNEINFLAMMATION AND CNS DISORDERS

The invention relates to a compound of the general formula (I) or a physiologically functional derivative, solvate or salt thereof, (I) wherein A is a bond, alkyl or alkoxy optionally substituted with one or more R" as defined herein, *-N(R"')CO-, *-CON(R"')-, *-N(R'")CON(R"')-, -S-, -SO-, *-N(R'")-, *-N(R'")CO-, *-CON(R'")-, -CO-, *-COO-, *-OOC-, *-S02N(R"')-, -S02, or *-N(R"')-SO2-, wherein R"' is as defined herein and * specifies the point of attachment to X; X is aryl, cycloalkyl, aralkyl, heterocyclyl or heteroaryl, which may be substituted with one or more Rx further described herein; L is a bond or *-N(RN)CO-, *-CON(RN)-, *-N(RN)-, *-C=N(RN)-, *-N(RN)-alkyI-, *-alkyl-N(RN)-, *-N(RN)CON(RN)-, *-CO-, *-S02-, alkyl, *-alkyl-0-alkyl-, *-NCO-CH=CH-, *-CH=CH-CONH-, * -S02N(RN)-, *-N(RN)S02-, or heterocyclyl, wherein * specifies the point of attachment to X; Y is H, alkyl, aryl, aralkyl, cycloalkyl, heterocyclyl or heteroaryl, which may be substituted with one or more RY further described herein; and R and RN are further described herein; as well as their use as a medicament, a pharmaceutical composition comprising them, a method of treatment or prevention of a medical condition entailing the administration thereof, and the use thereof in the manufacture of a medicament for the treatment or prevention of a medical condition, particularly autoimmune inflammatory disorders, CNS disorders, sleeping disorders, or proliferative diseases including cancer. The invention further relates to a specific process for the preparation of said compounds.

Difluoro-dioxolo-benzoimidazol-benzamides as potent inhibitors of CK1δ and ε with nanomolar inhibitory activity on cancer cell proliferation

Deregulation of CK1 (casein kinase 1) activity can be involved in the development of several pathological disorders and diseases such as cancer. Therefore, research interest in identifying potent CK1-specific inhibitors is still increasing. A previously p