173604-85-8Relevant academic research and scientific papers
N-SUBSTITUTED-CYCLIC AMINO DERIVATIVE
-
Page/Page column 158, (2012/05/20)
The present invention provides a compound of formula (I): wherein R1a is optionally substituted C1-6 alkyl, etc.; R1m is hydrogen atom, etc.; G1, G2, G3 and G4 are (i), etc. ((i) G1 is -N(R1b)-, G2 is -CO-, G3 is -C(R1c)(R1d)-, and G4 is oxygen, etc.); R1b is optionally substituted C1-6 alkyl, etc.; R1c and R1d are each independently optionally substituted C1-6 alkyl, etc.; R2 is optionally substituted C1-6 alkyl, etc.; R3a, R3b, R3c, and R3d are each independently a group: -A-B (A is a single bond, etc., B is hydrogen atom, etc.), etc.; n is 1, etc.; R5 is C1-4 alkoxycarbonyl, etc., or a pharmaceutically acceptable salt thereof, which is useful as a renin inhibitor.
Investigation of (oxodioxolenyl)methyl carbamates as nonchiral bioreversible prodrug moieties for chiral amines
Alexander, Jose,Bindra, Dilbir S.,Glass, Joan D.,Holahan, Marie A.,Renyer, Mara L.,Rork, Gerald S.,Sitko, Gary R.,Stranieri, Maria T.,Stupienski, Raymond F.,Veerapanane, Hemalata,Cook, Jacquelynn J.
, p. 480 - 486 (2007/10/03)
The preparation of(oxodioxolenyl)methyl carbamates and their evaluation as novel nonchiral prodrug moieties for chiral primary and secondary amino functional drugs are described. 4-(Carbamoylmethyl)-2-oxo-1,3-dioxolene derivatives of 3,4-dimethoxyphenethy
A convenient method for the conversion of halides to alcohols
Alexander,Renyer,Veerapanane
, p. 3875 - 3881 (2007/10/03)
The displacement of halides in unactivated primary bromides and iodides, allylic and benzylic primary and secondary bromides, and primary and secondary α-bromoketones by formate, using triethylammonium formate as the formylating agent, followed by acid or base catalyzed hydrolysis has been found to be an efficient method for the conversion of halides to alcohols.
