80715-20-4

Usage

Type of compound

Heterocyclic compound

Structure

Contains a dioxolone ring and a phenyl group

Bromomethyl group attachment

Position 4 of the dioxolone ring

Primary use

Organic synthesis as a building block for complex molecules

Utility

Useful precursor in the synthesis of biologically active compounds and pharmaceutical products

Phenyl group property

Confers aromatic and hydrophobic properties to the molecule

Application

Exploited in drug design and related applications

Upstream product

• 40352-53-2 4-phenyl-5-methyl-1,3-dioxol-4-en-2-one 
• 2114-00-3 2-bromo-1-phenyl-1-propanone 
• 5650-40-8 2-hydroxypropiophenone 
• 93-55-0 1-phenyl-propan-1-one 
• 93-54-9 1-Phenyl-1-propanol 

Downstream Products

• 108331-00-6 mecillinam (2-oxo-5-phenyl-1,3-dioxol-4-yl)methyl ester hydrochloride 
• 93034-36-7 4-iodomethyl-2-oxo-5-phenyl-1,3-dioxolene 
• 137713-29-2 5-Phenyl-4-phenylthiomethyl-1,3-dioxol-2-one 
• 137713-30-5 4-(4-Nitrophenylthio)methyl-5-phenyl-1,3-dioxol-2-one 
• 172688-07-2 (2-oxo-5-phenyl-1,3-dioxol-4-yl)methylformate 
• 173604-88-1 (5-phenyl-2-oxo-1,3-dioxol-4-en-4-yl)methyl p-nitrophenyl carbonate 
• 173604-85-8 4-(hydroxymethyl)-5-phenyl-1,3-dioxol-4-en-2-one 
• 80715-21-5 ampicillin (2-oxo-5-phenyl-1,3-dioxolen-4-yl)methyl ester hydrochloride 
• 85871-32-5 1,1-dioxopenicillanic acid (5-phenyl-2-oxo-1,3-dioxolen-4-yl)-methyl ester 

Relevant academic research and scientific papers

Influenza virus replication inhibitors and uses thereof (by machine translation)

The invention provides a compound as an influenza virus replication inhibitor, a method for preparing the same, a pharmaceutical composition containing the compound and application. (by machine translation)

N-SUBSTITUTED-CYCLIC AMINO DERIVATIVE

The present invention provides a compound of formula (I): wherein R1a is optionally substituted C1-6 alkyl, etc.; R1m is hydrogen atom, etc.; G1, G2, G3 and G4 are (i), etc. ((i) G1 is -N(R1b)-, G2 is -CO-, G3 is -C(R1c)(R1d)-, and G4 is oxygen, etc.); R1b is optionally substituted C1-6 alkyl, etc.; R1c and R1d are each independently optionally substituted C1-6 alkyl, etc.; R2 is optionally substituted C1-6 alkyl, etc.; R3a, R3b, R3c, and R3d are each independently a group: -A-B (A is a single bond, etc., B is hydrogen atom, etc.), etc.; n is 1, etc.; R5 is C1-4 alkoxycarbonyl, etc., or a pharmaceutically acceptable salt thereof, which is useful as a renin inhibitor.

PRODRUGS OF IMIDAZOLE CARBOXYLIC ACIDS AS ANGIOTENSIN II RECEPTOR ANTAGONISTS

Prodrugs of imidazole carboxylic acids which are AII antagonists useful in treating hypertension, pharmaceutical compositions thereof and a method of treating hypertension using such prodrugs are disclosed.

Ester of 1,1-dioxopenicillanic acid, and use thereof as β-lactamase inhibitor

A 1,1-dioxopenicillanic acid ester represented by formula (I) STR1 wherein R represents a methyl or phenyl group. The ester of formula (I) may be prepared by reacting 1,1-dioxopenicillanic acid or its salt with a compound represented by formula (III) STR2 wherein R is as defined above, and X represents a halogen atom, or by oxidizing a compound of formula (V) STR3 wherein R is as defined above. The ester of the formula (I) is useful as a β-lactamase inhibitor and may be used in association with a β-lactam antibiotic.

1,3-Dioxolen-2-one derivatives and process for production thereof

A 1,3-dioxolen-2-one derivative of the general formula STR1 wherein R1 represents a hydrogen atom, a methyl group, or an aryl group, R2 represents a hydrogen atom, or may be taken together with R1 to form a divalent carbon chain residue, and x represents a halogen atom. The above compounds can be prepared by reacting a compound of the general formula STR2 with a halogenating agent, and are useful as protective group-introducing reagents for introducing protective groups into reagents in various chemical reactions, or as modifiers for prodrug preparation in medicine.