17371-59-4Relevant academic research and scientific papers
A Star-Shaped Triazine-Based Vitamin B5 Copper(II) Nanocatalyst for Tandem Aerobic Synthesis of Bis(indolyl)methanes
Hasanpour, Benyamin,Jafarpour, Maasoumeh,Eskandari, Ameneh,Rezaeifard, Abdolreza
, p. 4122 - 4129 (2020)
In this work, the catalytic efficiency of a novel bio-relevant triazine (TA)-based pantothenate (vitamin B5) copper(II) complex [Cu(II)-TA/B5] in the aerobic oxidation of benzyl alcohols and tandem synthesis of bis(indolyl)methanes was exploited. The star-shaped catalyst was characterized by different techniques such as FT-IR, EDX, ICP, TEM, and TGA. TEM images revealed a honeycomb structure resulting from the accumulation of nanoparticles with size ranging between 2–6 nm. The high yields and excellent selectivity were obtained for the production of various benzaldehydes and bis(indolyl)methanes under aerobic conditions. Recycling tests, spectroscopic data, and leaching experiments testified that the title heterogeneous bio-relevant catalyst preserved its activity and structural integrity during oxidation and coupling reactions. The presented catalytic systems qualify all requirements for efficient catalytic systems for applied goals.
Application of natural kaolin supported sulfuric acid as an ecofriendly catalyst for the efficient synthesis of bis(indolyl)methanes
Gordi, Zinat,Eshghi, Shaghayegh,Eshghi, Shohreh
, p. 905 - 908 (2012)
The acidified kaolin with sulfuric acid (2% w/w) is introduced as a novel, mild, highly efficient, easily prepared, very cheap, recyclable and ecofriendly catalyst in organic synthesis. This catalyst has been used successfully for the synthesis of bis(ind
An efficient preparation of bis(indole)methanes catalyzed by tetrakis[3,5-bis(trifluoromethyl)phenyl]borate salts in aqueous medium
Liao, Bei-Sih,Chen, Jwu-Ting,Liu, Shiuh-Tzung
, p. 3125 - 3128 (2007)
An efficient and direct preparation of bis(indole)methanes from indole and the corresponding carbonyl compound in water catalyzed by metal salts of tetrakis[3,5-bis(trifluoromethyl)phenyl]borate has been developed. Georg Thieme Verlag Stuttgart.
Amberlyst-catalyzed reaction of indole: Synthesis of bisindolylalkane
Ke, Bowen,Qin, Yong,Wang, Yin,Wang, Fengpeng
, p. 1209 - 1212 (2005)
Amberlyst was found to be an effective catalyst for the condensation reactions of indoles 2 with aldehydes 3 to afford bisindolylalkanes 1 in good to excellent yields. Copyright Taylor & Francis, Inc.
ZnCl2/urea as a deep eutectic solvent for the preparation of bis(indolyl)methanes under ultrasonic conditions
Seyedi, Neda,Khabazzadeh, Hojatollah,Saeednia, Samira
, p. 1501 - 1505 (2015)
This work describes the synthesis of bis(indolyl)methanes by using effective combination of ultrasound and deep eutectic solvent. This methodology offers momentous improvements over various options for the synthesis of bis(indolyl)methanes with regard to
Efficient RuIII-catalyzed condensation of indoles and aldehydes or ketones
Tabatabaeian, Khalil,Mamaghani, Manouchehr,Mahmoodi, Nosratollah,Khorshidi, Alireza
, p. 1541 - 1545 (2006)
Synthesis of bis(indolyl)methanes through condensation of indoles and various aldehydes or ketones, using RuIII as catalyst, is reported. It was found that the catalytic system involving RuIII affords the products smoothly under very
A solvent-free protocol for facile condensation of indoles with carbonyl compounds using silica chloride as a new, highly efficient, and mild catalyst
Hasaninejad, Alireza,Zare, Abdolkarim,Sharghi, Hashem,Shekouhy, Mohsen,Khalifeh, Reza,Beni, Alireza Salimi,Zare, Ahmad Reza Moosavi
, p. 416 - 420 (2007)
A simple and efficient solvent-free procedure for the preparation of bis(indolyl)methanes via electrophilic substitution reactions of indoles with aldehydes and ketones is described. The reactions took place in the presence of a catalytic amount of silica
Bis-indolylation of aldehydes and ketones using silica-supported FeCl3: Molecular docking studies of bisindoles by targeting SARS-CoV-2 main protease binding sites
Deb, Barnali,Debnath, Sudhan,Chakraborty, Ankita,Majumdar, Swapan
, p. 30827 - 30839 (2021/11/19)
We report herein an operationally simple, efficient and versatile procedure for the synthesis of bis-indolylmethanes via the reaction of indoles with aldehydes or ketones in the presence of silica-supported ferric chloride under grindstone conditions. The prepared supported catalyst was characterized by SEM and EDX spectroscopy. The present protocol has several advantages such as shorter reaction time, high yield, avoidance of using harmful organic solvents during the reaction and tolerance of a wide range of functional groups. Molecular docking studies targeted toward the binding site of SARS-CoV-2 main protease (3CLpro or Mpro) enzymes were investigated with the synthesized bis-indoles. Our study revealed that some of the synthesized compounds have potentiality to inhibit the SARS-CoV-2 Mpro enzyme by interacting with key amino acid residues of the active sites via hydrophobic as well as hydrogen bonding interactions.
Photoinduced Skeletal Rearrangement of Diarylethenes: Photorelease of Lewis Acid and Synthetic Applications
Zakharov, Alexey V.,Yadykov, Anton V.,Gaeva, Elena B.,Metelitsa, Anatoly V.,Shirinian, Valerii Z.
, p. 16806 - 16814 (2021/11/16)
The skeletal photorearrangement including 6π-electrocyclization induced by UV light ofortho-halogen-substituted diarylethenes has been studied. It has been found that the reaction pathways leading to bi- or tricyclic frameworks depend on the kind of halog
Copper-catalyzed N-arylation of bis(indolyl)methanes: The first approach for the synthesis of unsymmetrical N-aryl bis(indolyl)methanes by C–N cross-coupling reaction
Bagheri, Fatemeh Hassani,Fayazi, Maryam,Khabazzadeh, Hojatollah
, p. 305 - 317 (2021/10/02)
This investigation describes an efficient method for the synthesis of unsymmetrical N-aryl bis(indolyl)methanes by C–N cross-coupling reaction of unsubstituted bis(indolyl)methanes with aryl iodides in the presence of several Cu salts and CuFe2
