173901-95-6

Basic information

• Product Name: 4-[4-(3-Cyclopentylpropyl)-5-oxo-4,5-dihydro-1H-tetrazol-1-yl]-N-[4-[2-[2(R)-hydroxy-2-(3-pyridyl)ethylamino]ethyl]phenyl]benzenesulfonamide
• Synonyms: L-770644
• CAS NO: 173901-95-6
• Molecular Formula: C₃₀H₃₇N₇O₄S
• Molecular Weight: 591.73789
• Mol File: 173901-95-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-[4-(3-Cyclopentylpropyl)-5-oxo-4,5-dihydro-1H-tetrazol-1-yl]-N-[4-[2-[2(R)-hydroxy-2-(3-pyridyl)ethylamino]ethyl]phenyl]benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[4-(3-Cyclopentylpropyl)-5-oxo-4,5-dihydro-1H-tetrazol-1-yl]-N-[4-[2-[2(R)-hydroxy-2-(3-pyridyl)ethylamino]ethyl]phenyl]benzenesulfonamide(173901-95-6)
• EPA Substance Registry System: 4-[4-(3-Cyclopentylpropyl)-5-oxo-4,5-dihydro-1H-tetrazol-1-yl]-N-[4-[2-[2(R)-hydroxy-2-(3-pyridyl)ethylamino]ethyl]phenyl]benzenesulfonamide(173901-95-6)

Safety Data

• Hazardous Substances Data: 173901-95-6(Hazardous Substances Data)

Upstream product

• 182251-90-7 4-(3-cyclopentylpropyl)-1-(4-nitrophenyl)-5-tetrazolone 
• 182251-91-8 1-(4-aminophenyl)-4-(3-cyclopentylpropyl)-5-tetrazolone 
• 182251-87-2 4-(3-cyclopentylpropyl)-1-phenyl-5-tetrazolone 
• 106211-63-6 3-cyclopentyl-1-iodopropane 
• 103-71-9 phenyl isocyanate 
• 5097-82-5 5-phenyl-1H-tetrazolone 
• 121-57-3 4-aminobenzene sulfonic acid 
• 211371-10-7 N-(2,2-diethoxy-2-pyridin-3-yl-ethyl)-2-(4-nitro-phenyl)-acetamide 
• 202873-15-2 N-(2-hydroxy-2-pyridin-3-yl-ethyl)-2-(4-nitro-phenyl)-acetamide 
• 211371-13-0 2-(4-amino-phenyl)-N-(2-hydroxy-2-pyridin-3-yl-ethyl)-acetamide 
• 202873-14-1 2-(4-nitro-phenyl)-N-(2-oxo-2-pyridin-3-yl-ethyl)-acetamide 
• 197146-48-8 methanesulfonic acid 3-cyclopentyl-propyl ester 
• 197146-49-9 1-(cyclopentyl)-3-propylazide 
• 182251-92-9 4-[(3-cyclopentylpropyl)-5-oxo-4,5-dihydrotetrazol-1-yl]phenylsulfonyl chloride 

Relevant articles and documents

L-770,644: A potent and selective human β3 adrenergic receptor agonist with improved oral bioavailability

L-770,644 (9c) is a potent and selective agonist of the human β3 adrenergic receptor (EC50 = 13 nM). It shows good oral bioavailability in both dogs and rats (%F = 27), and is a full agonist for glycerolemia in the rhesus monkey (ED50 = 0.21 mg/kg). Based on its desirable in vitro and in vivo properties, L-770,644 was chosen for further preclinical evaluation.

SUBSTITUTED SULFONAMIDES AS SELECTIVE BETA3 AGONISTS FOR THE TREATMENT OF DIABETES AND OBESITY

Substituted sulfonamides are selective β 3 adrenergic receptor agonists with very little β 1 and β 2 adrenergic receptor activity and as such the compounds are capable of increasing lipolysis and energy expenditure in cells. The compounds thus have potent