17403-07-5

Basic information

• Product Name: 3-(1-METHYL-4-PIPERIDINYL)INDOLE
• Synonyms: 3-(1-METHYL-4-PIPERIDINYL)INDOLE;3-(N-Methylpiperidinyl)indole;3-(1-Methylpiperidin-4-yl)-1H-indole;3-(1-methylpiperidin-2-yl)-1H-indole;3-(1-methyl-4-piperidinyl)-1H-Indole
• CAS NO: 17403-07-5
• Molecular Formula: C₁₄H₁₈N₂
• Molecular Weight: 214.31
• Product Categories: pharmacetical;Heterocycles;Indole Derivatives;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 17403-07-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 373.4°Cat760mmHg
• Flash Point: 179.6°C
• Appearance: Off-white to yellow/Solid
• Density: 1.103g/cm³
• Vapor Pressure: 9E-06mmHg at 25°C
• Refractive Index: 1.618
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• CAS DataBase Reference: 3-(1-METHYL-4-PIPERIDINYL)INDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(1-METHYL-4-PIPERIDINYL)INDOLE(17403-07-5)
• EPA Substance Registry System: 3-(1-METHYL-4-PIPERIDINYL)INDOLE(17403-07-5)

Safety Data

• Hazardous Substances Data: 17403-07-5(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 17403-07-5 differently. You can refer to the following data:
1. A piperidine-indole compound as 5-HT6 receptor inhibitor.
2. A piperidine-indole compound as 5-HT6 receptor inhibitor. Naratriptan (N378730) impurity A.

InChI:InChI=1/C14H18N2/c1-16-8-6-11(7-9-16)13-10-15-14-5-3-2-4-12(13)14/h2-5,10-11,15H,6-9H2,1H3

Upstream product

• 13669-28-8 1-methyl-4-methylene-1-azacyclohexane 
• 201230-82-2 carbon monoxide 
• 100-63-0 phenylhydrazine 
• 1445-73-4 1-Methyl-4-piperidone 
• 17403-03-1 3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole 
• 106-52-5 N-methyl-4-hydroxypiperidine 
• 120-72-9 indole 

Relevant articles and documents

Observations concerning the synthesis of tryptamine homologues and branched tryptamine derivatives via the borrowing hydrogen process: Synthesis of psilocin, bufotenin, and serotonin

Observations concerning the synthesis of substituted tryptamine derivatives starting from indoles and 1,n-amino alcohols via the borrowing hydrogen process are discussed. This catalytic, single-step, and modular approach to tryptamines and homotryptamines allows the synthesis of branched and nonbranched tryptamines as well as tryptamine-based natural products such as psilocin, bufotenin, and serotonin.

Synthesis of pharmacologically relevant indoles with amine side chains via tandem hydroformylation/fischer indole synthesis

The sequence of hydroformylation and Fischer indole synthesis starting from amino olefins and aryl hydrazines is described. In a convergent manner, the two units bearing pharmacologically relevant substituents are assembled in the final indolization step. This modular and diversity-oriented approach to tryptamines and homotryptamines can be conducted in water and allows synthesis of branched and nonbranched tryptamines as well as tryptamine-based pharmaceuticals such as the 5-HT1D agonist L 775 606.