13669-28-8

Basic information

• Product Name: 1-Methyl-4-methylene-piperidine
• Synonyms: 1-Methyl-4-methylene-piperidine;Piperidine, 1-methyl,4-methylene-
• CAS NO: 13669-28-8
• Molecular Formula: C₇H₁₃N
• Molecular Weight: 111.18482
• Mol File: 13669-28-8.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 140.5 °C at 760 mmHg
• Flash Point: 30.8 °C
• Appearance: /
• Density: 0.87g/cm³
• Vapor Pressure: 6.13mmHg at 25°C
• Refractive Index: 1.475
• CAS DataBase Reference: 1-Methyl-4-methylene-piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-4-methylene-piperidine(13669-28-8)
• EPA Substance Registry System: 1-Methyl-4-methylene-piperidine(13669-28-8)

Safety Data

• Hazardous Substances Data: 13669-28-8(Hazardous Substances Data)

Usage

General Description

1-Methyl-4-methylene-piperidine is a chemical compound with the molecular formula C8H15N. It is a piperidine derivative with a methyl group and a methylene group attached to the piperidine ring. 1-Methyl-4-methylene-piperidine is used in the synthesis of various pharmaceuticals and organic compounds. It is also known to exhibit narcotic and analgesic properties, making it a potential candidate for developing new medications. Additionally, 1-Methyl-4-methylene-piperidine has been studied for its potential use as a local anesthetic and in the treatment of certain neurological disorders. However, it is important to handle this compound with caution as it can be toxic if not used properly.

InChI:InChI=1/C7H13N/c1-7-3-5-8(2)6-4-7/h1,3-6H2,2H3

Upstream product

• 1445-73-4 1-Methyl-4-piperidone 
• 65920-56-1 4-(bromomethyl)piperidine hydrobromide 
• 1570-45-2 isonicotinic acid ethylester 
• 55-22-1 pyridine-4-carboxylic acid 
• 6457-49-4 4-piperidinemethanol 
• 279-27-6 exo-1-azabicyclo[2.2.1]heptane 
• 931-20-4 1-methylpiperidin-2-one 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 7732-18-5 water 
• 72450-48-7 1-methyl-1-azonia-norbornane; iodide 
• 2065-66-9 methyl-triphenylphosphonium iodide 

Downstream Products

• 182563-08-2 5-(4-fluorobenzoyl)amino-3-(1-methylpiperidin-4-yl)-1H-indole 
• 17403-07-5 3-(1-methylpiperidin-4-yl)-1H-indole 
• 121206-76-6 5-Bromo-3-(1-methyl-4-piperidinyl)-1H-indole 
• 111963-87-2 5-methoxy-3-(1-methylpiperidin-4-yl)-1H-indole 
• 144282-55-3 ethyl 4-methylenepiperidine-1-carboxylate 
• 1135493-55-8 N-[3-(1-methylpiperidin-4-yl)-5-trifluoromethyl-phenyl]-acetamide 
• 160193-30-6 1-Ethyl-3-[2-(4-hydroxy-1-methyl-piperidin-4-yl)-1-phenyl-ethyl]-thiourea 
• 160193-29-3 1-[2-(4-Hydroxy-1-methyl-piperidin-4-yl)-1-phenyl-ethyl]-3-methyl-thiourea 
• 160193-19-1 1-methyl-4-hydroxy-4-(2'-phenyl-2'-aminoethyl)-piperidine 
• 160193-20-4 1-methyl-4-hydroxy-4-(2'-methyl-2'-aminoethyl)-piperidine 
• 156339-90-1 3-phenyl-8-methyl-1-oxa-2,8-diazaspiro<4,5>dec-2-ene 
• 26218-72-4 3,4-bis-(4-chloro-phenyl)-furazan 2-oxide 
• 5585-14-8 3,4-diphenyl-furazan 2-oxide 

Relevant articles and documents

Development of a Robust Process for the Preparation of High-Quality 4-Methylenepiperidine Hydrochloride

An efficient route for the preparation of 4-methylenepiperidine hydrochloride 1 was designed, and then a process feasible for large-scale production was developed with a total yield of 83.5% at a purity of 99.9%.

SUBSTITUTED ARYL-AMINE DERIVATIVES AND METHODS OF USE

The present invention provides classes of compounds, including-their pharmaceutically acceptable derivatives, useful for treating angiogenesis and related diseases such as cancer. Formula I and II wherein R is a 9- or 10-membered heterocyclyl ring selected from 7-isoquinolinyl,..2-methyl-3-oxo-2,3-dihydroindazol-6-yl, [1,6]-naphthydrin-3-yl, [1,7]-naphthydrin-2-yl, 1-oxo-2,3-dihydrobenzofuran-4-yl, 3-oxo-2,3-dihydrobenzofuran-5-yl, dihydro-benzodioxinyl, 6-quinazolinyl, 2-amino-6-quinazolinyl, 4-methylamino-6-quinazolinyl, 2,4-diamino-6 quinazolinyl, 3-oxo-3,4-dihydro-1,4-benzoxazin-6-yl, 2,2-difluoro-l;3-benzodioxol-5-yl and 2,2,3,3 tetrafluoro-2,3-dihydro-l,4-benzodioxin-6-yl, each of which is optionally substituted with one or more substituents selected from halo, haloakyl, C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, N-dimethylamino-C1-6-alkyl, N-dimethylamino-C1-6-alkoxy, amino, alkyl-carbonylamino, morpholino-sulfonyl, amino-sulfonyl, oxazolyl, pyrrolyl,4 morpholinyl, carboxyl, cyano, and acetyl; wherein R1 in formula I is selected from unsubstituted or substituted phenyl, 5-6 membered heteroaryl, 9-10 membered bicyclic heterocyclyl and 11-14 membered tricyclic heterocyclyl, and R1 in formula II is selected from specific bicyclic heterocycles.

Synthesis of pharmacologically relevant indoles with amine side chains via tandem hydroformylation/fischer indole synthesis

The sequence of hydroformylation and Fischer indole synthesis starting from amino olefins and aryl hydrazines is described. In a convergent manner, the two units bearing pharmacologically relevant substituents are assembled in the final indolization step. This modular and diversity-oriented approach to tryptamines and homotryptamines can be conducted in water and allows synthesis of branched and nonbranched tryptamines as well as tryptamine-based pharmaceuticals such as the 5-HT1D agonist L 775 606.