174175-00-9Relevant articles and documents
Synthesis and in vitro investigation of potential antiproliferative monosaccharide–D-secoestrone bioconjugates
Bodnár, Brigitta,Mernyák, Erzsébet,Szabó, Johanna,W?lfling, János,Schneider, Gyula,Zupkó, István,Kupihár, Zoltán,Kovács, Lajos
, p. 1938 - 1942 (2017/04/07)
The syntheses of monosaccharide–D-secoestrone conjugates are reported. They were prepared from 3-(prop-2-inyloxy)-D-secoestrone alcohol or oxime and monosaccharide azides via Cu(I)-catalyzed azide–alkyne cycloaddition reactions (CuAAC). The antiproliferat
Synthesis of 5'-fluoro-5'-deoxy- and 5'-amino-5'-deoxytoyocamycin and sangivamycin and some related derivatives
Sharma,Li,Ledvina,Bobek
, p. 1831 - 1852 (2007/10/02)
A series of 5'-substituted analogs of toyocamycin were prepared by condensation of silylated 4-amino-6-bromo-5-cyanopyrrolo[2,3-d]pyrimidine with protected 5-azido-5-deoxy- or 5-fluoro-5-deoxyribofuranose followed by debromination and deblocking. Alternatively, 5'-azido-5'-deoxytoyocamycin was prepared by azidation of toyocamycin. Conversion of the 5-nitrile function of the toyocamycin derivatives into a carboxamide or a thiocarboxamide gave the corresponding analogs of sangivamycin or thiosangivamycin while reduction of the 5'-azido-5'-deoxy nucleosides provided 5'-amino-5'-deoxy derivatives.