174292-59-2Relevant articles and documents
Synthesizing method of cis-3-hydroxy-cyclopentane carboxylate or cyclohexane carboxylate and derivative thereof
-
Paragraph 0043; 0044; 0045; 0046, (2018/07/30)
The invention discloses a synthesizing method of cis-3-hydroxy-cyclopentane carboxylate or cyclohexane carboxylate and a derivative thereof. The method includes: a compound III serving as the raw material and hydrogen are subjected to one-step ring-opening reaction in a solvent in the presence of alkali and a catalyst to prepare the cis-3-hydroxy-cyclopentane carboxylate or cyclohexane carboxylateand the derivative thereof. The method is simple and practicable, high in product yield and suitable for large-scale production.
Horse Liver Alcohol Dehydrogenase-catalyzed Enantioselective Reduction of Cyclic Ketones: The Effect of the Hydrophobic Side Chain of the Substrate on the Stereoselectivity of the Reaction
Shigematsu, Hajime,Matsumoto, Toshihiko,Kawauchi, Giichi,Hirose, Yoshiki,Naemura, Koichiro
, p. 3001 - 3008 (2007/10/03)
Horse liver alcohol dehydrogenase (HLADH)-catalyzed enantioselective reductions of alkyl 3-oxocyclopentanecarboxylates, endo-5-acyloxybicycloheptan-2-ones and exo-5-acyloxybicycloheptan-2-ones gave the corresponding homochiral alcohols and ketones and the interaction between the hydrophobic side chain of the substrate and the hydrophobic zone in the active site played an important role in the specificity of the reduction.The stereoselectivities of the reactions were interpreted on the basis of the cubic space section model and a new rule, which contributes to development of a specificity analysis on the basis of the model, is introduced.