17432-37-0

Basic information

• Product Name: 2 3 5 6-TETRAMETHYLBENZALDEHYDE 97
• Synonyms: 2 3 5 6-TETRAMETHYLBENZALDEHYDE 97
• CAS NO: 17432-37-0
• Molecular Formula: C₁₁H₁₄O
• Molecular Weight: 162.231
• Product Categories: Aldehydes;C10 to C21;Carbonyl Compounds
• Mol File: 17432-37-0.mol
• Article Data: 11

Chemical Properties

• Melting Point: 22-23 °C (C)(lit.)
• Boiling Point: 248.94°C (rough estimate)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.027 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.009mmHg at 25°C
• Refractive Index: n20/D 1.554(lit.)
• CAS DataBase Reference: 2 3 5 6-TETRAMETHYLBENZALDEHYDE 97(CAS DataBase Reference)
• NIST Chemistry Reference: 2 3 5 6-TETRAMETHYLBENZALDEHYDE 97(17432-37-0)
• EPA Substance Registry System: 2 3 5 6-TETRAMETHYLBENZALDEHYDE 97(17432-37-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 17432-37-0(Hazardous Substances Data)

Usage

General Description

2 3 5 6-Tetramethylbenzaldehyde 97 is a chemical compound that is composed of a benzene ring with four methyl groups attached to various positions. It is commonly used in the synthesis of various organic compounds and can be utilized in the production of fragrances and flavors. The chemical is also known for its mild aromatic and aldehydic odor. Additionally, it can act as a building block for creating pharmaceutical intermediates and has potential applications in the manufacturing of agrochemicals. It is important to handle this chemical with caution and to follow proper safety protocols when working with it.

InChI:InChI=1/C11H14O/c1-7-5-8(2)10(4)11(6-12)9(7)3/h5-6H,1-4H3

Upstream product

• 7435-83-8 3-(chloromethyl)-1,2,4,5-tetramethylbenzene 
• 4885-02-3 Dichloromethyl methyl ether 
• 95-93-2 1,2,4,5-tetramethylbenzene 
• 700-12-9 pentamethylbenzene, 
• 201230-82-2 carbon monoxide 
• 488-23-3 1,2,3,4-Tetramethylbenzene 
• 527-53-7 1,2,3,5-Tetramethylbenzene 
• 1646-53-3 bromodurene 
• 68-12-2 N,N-dimethyl-formamide 
• 1967-89-1 1,4-dichlorodurene 
• 138556-69-1 di(2,3,5,6-tetramethylbenzyl) peroxydicarbonate 
• 107-30-2 chloromethyl methyl ether 

Downstream Products

• 111439-13-5 2,3,5,6,2',3',5',6'-Octamethyl-benzhydrol 
• 72606-35-0 morpholin-4-yl-acetic acid (2,3,5,6-tetramethyl-benzylidene)-hydrazide 
• 116761-80-9 3-Methyl-1-(2,3,5,6-tetramethyl-phenyl)-butan-1-ol 
• 135962-97-9 2,3,5,6-tetramethylbenzylidene dichloride 
• 72606-31-6 C₁₄H₂₁N₃O 
• 72606-34-9 C₁₅H₂₃N₃O 
• 730916-06-0 2-Hydroxy-2-(2,3,5,6-tetramethyl-phenyl)-acetimidic acid ethyl ester 
• 1241906-87-5 (Z)-2-(2,3,5,6-tetramethylbenzylidene)-4,6-dimethoxy-2,3-dihydro-1H-indol-3-one 
• 107184-38-3 2,3,5,6,2',3',5',6'-octamethyl-benzhydryl chloride 
• 67075-68-7 bis(2,3,5,6-tetramethylphenyl)methanone 
• 88332-48-3 (Z)-9-(2,3,5,6-tetramethylstyryl)acridine 
• 527-35-5 2,3,5,6-tetramethylphenol 
• 148990-19-6 4-dichloromethyl-2,3,5,6-tetramethylbenzaldehyde 
• 7072-01-7 2,3,5,6-tetramethyl-1,4-benzenedicarboxaldehyde 

Relevant articles and documents

Differing activity profiles of the stereoisomers of 2,3,5,6TMP-TQS, a putative silent allosteric modulator of a7 nAChR

Many synthetic compounds to which we attribute specific activities are produced as racemic mixtures of stereoisomers, and it may be that all the desired activity comes from a single enantiomer. We have previously shown this to be the case with the a7 nicotinic acetylcholine receptor positive allosteric modulator (PAM) 3a,4,5,9b-Tetrahydro-4-(1-naphthalenyl)-3H-cyclopentan[ c]quinoline-8-sulfonamide (TQS) and the a7 ago-PAM 4BP-TQS. Cis-trans-4-(2,3,5,6-tetramethylphenyl)-3a,4,5,9b-tetrahydro- 3H-cyclopenta[c]quinoline-8-sulfonamide (2,3,5,6TMPTQS), previously published as a "silent allosteric modulator" and an antagonist of a7 allosteric activation, shares the same scaffold with three chiral centers as the aforementioned compounds. We isolated the enantiomers of 2,3,5,6TMP-TQS and determined that the (2) isomer was a significantly better antagonist than the (+) isomer of the allosteric activation of both wild-type a7 and the nonorthosterically activatible C190A a7 mutant by the ago-PAM GAT107 (the active isomer of 4BP-TQS). In contrast, (+)2,3,5,6TMPTQS proved to be an a7 PAM. (2)2,3,5,6TMP-TQS was shown to antagonize the allosteric activation of a7 by the structurally unrelated ago-PAM B-973B as well as the allosteric activation of the TQS-sensitive a4b2L159M mutant. In silico docking of 2,3,5,6TMP-TQS in the putative allosteric activation binding site suggested a specific interaction of the (2) enantiomer with a7T106, and allosteric activation of a7T106 mutants was not inhibited by (2)2,3,5,6TMP-TQS, confirming the importance of this interaction and supporting the model of the allosteric binding site. Comparisons and contrasts between 2,3,5,6TMP-TQS isomers and active and inactive enantiomers of other TQS-related compounds identify the orientation of the cyclopentenyl ring to the plane of the core quinoline to be a crucial determinate of PAM activity.

Aryllithiums with increasing steric crowding and lipophilicity prepared from chlorides in diethyl ether. the first directly prepared room-temperature-stable dilithioarenes

A convenient procedure has been developed for the preparation of synthetically useful, room-temperature-stable aryllithiums starting from aryl chlorides and lithium metal. The method provides a route to aryllithiums which have previously not been accessible cleanly or could only be prepared by using more expensive starting materials.

A new redox system: Trichloromethylarene - Pyridine base. On the mechanism of the synthesis of N-(4-pyridyl)pyridinium dichloride

A redox reaction of trichloromethylarenes with pyridines results in respective N-(α-chloroarylmethyl)-substituted pyridinium chlorides which give on hydrolysis aromatic aldehydes and 4-chloropyridines or 1,4'- bipyridinium salts.