556-10-5

Basic information

• Product Name: 4-NITROPHENYLUREA
• Synonyms: 4-NITROPHENYLUREA;N-(p-Nitrophenyl)urea;1-(4-Nitrophenyl)urea;1-(p-Nitrophenyl)urea;ENT 61327;NSC 227938;p-Nitrophenylurea
• CAS NO: 556-10-5
• Molecular Formula: C₇H₇N₃O₃
• Molecular Weight: 181
• Mol File: 556-10-5.mol
• Article Data: 24

Chemical Properties

• Melting Point: 150℃
• Boiling Point: 314.24°C (rough estimate)
• Flash Point: 160.2°C
• Appearance: /
• Density: 1.490
• Vapor Pressure: 8.15E-05mmHg at 25°C
• Refractive Index: 1.5860 (estimate)
• Solubility: soluble in Methanol,Ethanol,Dimethylformamide
• PKA: 13.79±0.70(Predicted)
• Merck: 14,6626
• CAS DataBase Reference: 4-NITROPHENYLUREA(CAS DataBase Reference)
• NIST Chemistry Reference: 4-NITROPHENYLUREA(556-10-5)
• EPA Substance Registry System: 4-NITROPHENYLUREA(556-10-5)

Safety Data

• Hazardous Substances Data: 556-10-5(Hazardous Substances Data)

Usage

Purification Methods

Crystallise the urea from EtOH or hot water. UV has max at 322nm (EtOH). [Beilstein 12 II 392, 12 III 1617, 12 IV 1645.]

InChI:InChI=1/C7H7N3O3/c8-7(11)9-5-1-3-6(4-2-5)10(12)13/h1-4H,(H3,8,9,11)

Upstream product

• 61700-60-5 N-(4-nitrophenyl)cyanamide 
• 100-28-7 4-Nitrophenyl isocyanate 
• 7647-01-0 hydrogenchloride 
• 29177-55-7 N-carbamoyl-4-nitrobenzenesulfonamide 
• 62-23-7 4-nitro-benzoic acid 
• 100-01-6 4-nitro-aniline 
• 57-13-6 urea 
• 98-95-3 nitrobenzene 
• 619-80-7 4-nitrobenzamide 
• 192332-48-2 N'-hydroxy-4-nitrobenzimidamide 
• 619-72-7 4-nitrobenzonitrile 
• 100-00-5 4-chlorobenzonitrile 
• 693831-23-1 C₁₅H₁₅N₃O₄ 
• 3696-22-8 p-nitrophenylthiourea 

Downstream Products

• 75457-06-6 N-(4-nitro-phenyl)-N'-(2,2,2-trichloro-1-hydroxy-ethyl)-urea 
• 13915-23-6 1-(2-methyl-4-oxo-4H-quinazolin-3-yl)-3-(4-nitro-phenyl)-urea 
• 144921-43-7 N-4-Nitrophenyl-N',N'-dioctylurea 
• 96236-88-3 N-(4-nitrophenyl)-N'-methoxymethylurea 
• 22751-18-4 N-(2,4-dinitro-phenyl)-N'-nitro-urea 
• 17433-93-1 4-(4-nitrophenyl)semicarbazide 
• 2589-20-0 N-(4-nitrophenyl)-N',N'-(1,5-pentamethylenediyl)urea 
• 27425-04-3 1-(4-nitrophenyl)barbituric acid 
• 26946-72-5 N-(4-nitrophenyl)-1,3-benzoxazol-2-amine 
• 1432624-40-2 2-(3,4,5-trimethoxystyryl)-4-(4-nitrophenylureido)-quinazoline 
• 1401252-80-9 3-(4-nitrophenylureido)carbonyl-N₁-ethyl-6-hydroxy-4-oxo-pyrido[2,3-h]quinoline 

Relevant articles and documents

Templated synthesis of copper(II) azacyclam complexes using urea as a locking fragment and their metal-enhanced binding tendencies towards anions

Copper(II) azacyclam complexes 32+ and 42+ were obtained through a metal-templated procedure involving the pertinent open-chain tetramine, formaldehyde and a phenylurea derivative as a locking fragment. Both metal complexes can estab

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Design and synthesis of novel N-(4-(Pyridin-2-yloxy)benzylidene)-4-[4-(substituted)phenyl]semicarbazides as potential anticonvulsant agents

A new series of N-(4-(pyridin-2-yloxy)benzylidene)-4-[4-(substituted)phenyl]semicarbazides (PSSD1-8) were designed and synthesized keeping in view the structural requirement of pharmacophore and evaluated for their possible anticonvulsant activity. All the derivatives were synthesized by the given scheme and reaction process was monitored by thin layer chromatography. The structure of synthesized derivatives was confirmed by FT-IR, 1H NMR, mass spectroscopy and elemental analysis. The anticonvulsant activity was established after intraperitoneal administration in MES and scMET seizure models. The most active compound of the series was 1-(4-(pyridin-2-yloxy)-benzylidene)-4-p-tolylsemicarbazide (PSSD5). A molecular docking study was carried out in order to assess the interaction and binding modes with target receptor/enzyme. Titled compounds were found to strongly bind to human gamma-aminobutyric acid receptor (GABAAR-β3). A computational study was also carried to predict the pharmacokinetic properties of the synthesized compounds.