174485-31-5Relevant academic research and scientific papers
Non-peptidic HIV protease inhibitors: C2-symmetry-based design of bis- sulfonamide dihydropyrones
Janakiraman, Musiri N.,Watenpaugh, Keith D.,Tomich, Paul K.,Chong, Kong-Teck,Turner, Steve R.,Tommasi, Ruben A.,Thaisrivongs, Suvit,Strohbach, Joseph W.
, p. 1237 - 1242 (2007/10/03)
Potent, non-peptidic, dihydropyrone sulfonamide HIV protease inhibitors have been previously described. Crystallographic analysis of dihydropyrone sulfonamide inhibitor/HIV protease complexes suggested incorporation of a second, C2 symmetry-rel
PYRANONE COMPOUNDS USEFUL TO TREAT RETROVIRAL INFECTIONS
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, (2008/06/13)
The present invention relates to compounds of formulae (I) and (II) which are pyran-2-ones, 5,6-dihydro-pyran-2-ones, 4-hydroxy-benzopyran-2-ones, 4-hydroxy-cycloalkyl[b]pyran-2-ones, and derivatives thereof, useful for inhibiting a retrovirus in a mammalian cell infected with said retrovirus, wherein R 10 and R 20 taken together are formulae (III) and (IV). STR1
