174485-36-0

Upstream product

• 459-31-4 3-(4-fluorophenyl)propanoic acid 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 459-57-4 4-fluorobenzaldehyde 
• 136265-10-6 ethyl 4-fluorocinnamate 
• 772-70-3 3-(4-fluorophenyl)propanoyl chloride 

Downstream Products

• 63416-70-6 3-(4-fluorophenyl)propanal 
• 1267878-41-0 1,1,1-trifluoro-4-(4-fluorophenyl)butan-2-one 
• 852660-77-6 3-(4-fluorophenyl)-N-propylpropan-1-amine 
• 852660-82-3 C₂₂H₃₆FN₃O 
• 852661-47-3 N-((1R,3S,4R)-4-amino-3-(((3-(4-fluorophenyl)propyl)(propyl)amino)methyl)-cyclohexyl)pivalamide 
• 852660-79-8 C₂₇H₃₅FN₂O₃ 
• 852661-43-9 1-((1R,2S,4R)-2-(((3-(4-fluorophenyl)propyl)(propyl)amino)methyl)-4-pivalamidocyclohexyl)-3-(1,3,4-thiadiazol-2-yl)urea 
• 852661-48-4 1-((1R,2S,4R)-2-(((3-(4-fluorophenyl)propyl)(propyl)amino)methyl)-4-pivalamidocyclohexyl)-3-(5-methyl-1,3,4-thiadiazol-2-yl)urea 
• 852660-75-4 N-(3-acetylphenyl)-N'-[(1R,2S,5R)-5-(N-methyl)acetamido-2-[N-propyl-3-(4-fluorophenyl)propylamino]methyl-cyclohexyl]urea 
• 852660-76-5 N-(3-acetylphenyl)-N'-[(1R,2S,5S)-5-(N-methyl)acetamido-2-[N-propyl-3-(4-fluorophenyl)propylamino]methyl-cyclohexyl]urea 
• 852661-49-5 1-((1R,2S,4R)-2-(((3-(4-fluorophenyl)propyl)(propyl)amino)methyl)-4-pivalamidocyclohexyl)-3-(5-ethyl-1,3,4-thiadiazol-2-yl)urea 

Relevant academic research and scientific papers

'Wake-Up Call of A Sleeping Beauty': Straightforward Synthesis of Functionalized β-(2-Pyridyl) Ketones from 2,6-Lutidine

β-(2-Pyridyl) ketones are a unique class of heterocycles with valuable physicochemical properties and emerging relevance as pharmacophores. Herein we report a one-step process for the preparation of various substituted β-(2-pyridyl) ketones from the common starting material, 2,6-lutidine. Furthermore, we demonstrate the utility of this building block by synthesizing of a small set of antimalarial natural products.

Difunctionalization of ketones: Via gem -bis(boronates) to synthesize quaternary carbon with high selectivity

All-carbon quaternary centres are significant and prevalent structural frameworks but their preparation routes are rare and challenging, especially methods with common substrates. Herein, we report a convenient process to construct all-carbon quaternary c

A Weinreb amide approach to the synthesis of trifluoromethylketones

A novel route to access trifluoromethylketones (TFMKs) from Weinreb amides is reported. This represents the first documented case of the Ruppert-Prakash reagent (TMS-CF3) reacting in a constructive manner with an amide and enables synthesis of TMFKs without risk of over-trifluoromethylation.

N-UREIDOALKYL-AMINO COMPOUNDS AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

The present application describes modulators of chemokine receptors of formula (I), or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases.

NITROGEN-CONTAINING HETEROARYL COMPOUNDS HAVING HIV INTEGRASE INHIBITORY ACTIVITY

A compound of the formula (I): wherein Z4, Z5 and Z9 each is independently carbon atom or nitrogen atom; Y is hydroxy, mercapto or amino; RA is a group of the formula: (wherein C ring is nitrogen-containing heteroaryl) has an inhibitory activity against integrase.