174497-80-4

Basic information

• Product Name: di-tert-butyl 3-methyl hexahydropyridazine-1,2,3-tricarboxylate
• CAS NO: 174497-80-4
• Molecular Weight: 344.408
• Mol File: 174497-80-4.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: di-tert-butyl 3-methyl hexahydropyridazine-1,2,3-tricarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: di-tert-butyl 3-methyl hexahydropyridazine-1,2,3-tricarboxylate(174497-80-4)
• EPA Substance Registry System: di-tert-butyl 3-methyl hexahydropyridazine-1,2,3-tricarboxylate(174497-80-4)

Safety Data

• Hazardous Substances Data: 174497-80-4(Hazardous Substances Data)

Upstream product

• 2049-80-1 (2-propenyl)propanedioic acid diethyl ester 
• 1397580-76-5 2-allyl-2-(N,N'-di-tert-butoxycarbonylhydrazino)malonic acid diethyl ester 
• 1397582-66-9 C₁₇H₃₂N₂O₉S 
• 1397582-19-2 2-(N,N'-di-tert-butoxycarbonylhydrazino)-5-hydroxypentanoic acid methyl ester 
• 1397581-25-7 2-(N,N'-di-tert-butoxycarbonylhydrazino)pent-4-enoic acid methyl ester 
• 1161000-95-8 di-tert-butyl 3-methyl-1,2,3,6-tetrahydropyridazine-1,2,3-tricarboxylate 
• 67-56-1 methanol 
• 186581-53-3 diazomethane 
• 1219380-72-9 N,N'-di-tert-butoxycarbonylpiperazic acid 
• 156699-39-7 (3S)-N,N'-bis-(t-butoxycarbonyl)hexahydropyridazine-3-carboxylic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 1219114-45-0 di-tert-butyl 3-[(S)-4-benzyl-2-oxo-1,3-oxazolidine-3-carbonyl]hexahydropyridazine-1,2-dicarboxylate 
• 156699-38-6 (4S)-3-<(3S)-N,N'-bis(t-butoxycarbonyl)hexahydropyridazine-3-carboxy>-4-phenylmethyl-2-oxazolidinone 
• 146232-50-0 (4R)-3-<(3R)-N,N'-bis(t-butoxycarbonyl)hexahydropyridazine-3-carboxy>-4-phenylmethyl-2-oxazolidinone 

Relevant articles and documents

MACROCYCLIC INHIBITORS OF FLAVIVIRIDAE VIRUSES

Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of virus infections, particularly hepatitis C infections.

MACROCYCLIC INHIBITORS OF FLAVIVIRIDAE VIRUSES

Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of virus infections, particularly hepatitis C infections.

Synthesis of the tripeptide domain of sanglifehrins using asymmetric phase-transfer catalysis

The tripeptide (S)-valinyl-(S)-m-hydroxyphenylalanyl-(3S)-piperazate common to immunosuppressant sanglifehrins was synthesized from the constituent amino acid residues in nine steps and 42% overall yield. A key construction was the installation of (S) absolute configuration in m-hydroxyphenylalanine using asymmetric phase-transfer catalysis in the presence of N-(1-naphthyl) cinchonidinium bromide. Cbz-protected (S)-valine was first coupled to the amino group of (S)-m-triisopropylsilyloxyphenylalanine tert-butyl ester, and the resulting dipeptide after ester cleavage was linked to (3S)-methyl piperazate.