174672-58-3

Basic information

• Product Name: 2-Thiophenecarboxylicacid,5-ethynyl-(9CI)
• Synonyms: 2-Thiophenecarboxylicacid,5-ethynyl-(9CI)
• CAS NO: 174672-58-3
• Molecular Formula: C₇H₄O₂S
• Molecular Weight: 152.17046
• Product Categories: CARBOXYLICACID
• Mol File: 174672-58-3.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Thiophenecarboxylicacid,5-ethynyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Thiophenecarboxylicacid,5-ethynyl-(9CI)(174672-58-3)
• EPA Substance Registry System: 2-Thiophenecarboxylicacid,5-ethynyl-(9CI)(174672-58-3)

Safety Data

• Hazardous Substances Data: 174672-58-3(Hazardous Substances Data)

Upstream product

• 62224-19-5 5-bromo-2-thiophenecarboxylic acid methyl ester 
• 7311-63-9 5-bromothiophene-2-carboxylic acid 
• 177575-35-8 5-trimethylsilanylethynylthiophene-2-carboxylic acid methyl ester 
• 881736-66-9 ethyl 5-(2-trimethylsilyl-ethyn-1-yl)-thiophene-2-carboxylate 

Downstream Products

• 1519035-42-7 C₅₂H₄₈Mo₂N₆O₈S 
• 1436861-03-8 Mo₂(2,4,6-triisopropyl benzoate)2(5-ethynylthiophene-2-carboxylate)2 
• 1436861-04-9 W₂(2,4,6-triisopropyl benzoate)2(5-ethynylthiophene-2-carboxylate)2 
• 1316652-58-0 5-ethynylthiophene-2-carboxylic acid 2-aminophenylamide 
• 1316651-80-5 C₂₄H₂₇N₅OS 
• 1316651-77-0 C₂₀H₂₃N₅OS 
• 1316651-74-7 C₁₉H₂₁N₅OS 
• 1316651-73-6 C₂₄H₁₉N₅OS 
• 1316651-72-5 C₂₄H₁₉N₅OS 
• 1316651-71-4 C₂₆H₂₁N₅O₂S 
• 1316651-68-9 C₂₆H₂₁N₅O₂S 
• 1316651-65-6 C₂₆H₂₁N₅OS 
• 1316651-64-5 C₂₆H₂₁N₅OS 
• 1316651-63-4 C₂₁H₁₉N₅O₂S 

Relevant articles and documents

D-π-A structured porphyrins for efficient dye-sensitized solar cells

In this study, new push-pull alkoxy-wrapped zinc porphyrin dyes with intramolecular donor-π-acceptor structures have been designed and synthesized for dye-sensitized solar cells (DSCs). The linkers based on thiophene or 2,3-dihydrothieno[3,4-b][1,4] dioxine with cyanoacetic acid can broaden the spectral response of porphyrins into the near-IR region (～850 nm), which is mainly attributed to the cyanoacetic acid group. However, porphyrins with cyanoacrylic acid as an anchoring group lead to a faster charge recombination rate at the dye-sensitized heterojunction interface, which lowers the device photovoltaic performance. By using porphyrins with a rigid π-linker feature structure that is 5-ethynylthiophene-2-carboxylic acid, highly efficient DSC devices with a power conversion efficiency of 9.5% can be obtained. Spectral, electrochemical, photovoltage transient decay and impedance measurements are performed to reveal the influence of π-conjugated linkers and anchoring groups upon the optoelectronic features of porphyrin dyes in DSCs.

RET INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

Provided herein are a RET inhibitor, a pharmaceutical composition thereof and uses thereof. In particular, provided is a compound having Formula (I) or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof. Provided is a pharmaceutical composition comprising the compound, and uses of the compound and pharmaceutical composition thereof for the preparation of a medicament, in particular for treatment and prevention of RET-related diseases and conditions, including cancer, irritable bowel syndrome, and/or pain associated with irritable bowel syndrome.

Rapid discovery of highly potent and selective inhibitors of histone deacetylase 8 using click chemistry to generate candidate libraries

To find HDAC8-selective inhibitors, we designed a library of HDAC inhibitor candidates, each containing a zinc-binding group that coordinates with the active-site zinc ion, linked via a triazole moiety to a capping structure that interacts with residues on the rim of the active site. These compounds were synthesized by using click chemistry. Screening identified HDAC8-selective inhibitors including C149 (IC50 = 0.070 μM), which was more potent than PCI-34058 (6) (IC50 = 0.31 μM), a known HDAC8 inhibitor. Molecular modeling suggested that the phenylthiomethyl group of C149 binds to a unique hydrophobic pocket of HDAC8, and the orientation of the phenylthiomethyl and hydroxamate moieties (fixed by the triazole moiety) is important for the potency and selectivity. The inhibitors caused selective acetylation of cohesin in cells and exerted growth-inhibitory effects on T-cell lymphoma and neuroblastoma cells (GI50 = 3-80 μM). These findings suggest that HDAC8-selective inhibitors have potential as anticancer agents.