174893-22-2

Basic information

• Product Name: cis-1,3-cyclohexanedi(tert-butoxycarbonyl)amine
• CAS NO: 174893-22-2
• Molecular Weight: 314.425
• Mol File: 174893-22-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: cis-1,3-cyclohexanedi(tert-butoxycarbonyl)amine(CAS DataBase Reference)
• NIST Chemistry Reference: cis-1,3-cyclohexanedi(tert-butoxycarbonyl)amine(174893-22-2)
• EPA Substance Registry System: cis-1,3-cyclohexanedi(tert-butoxycarbonyl)amine(174893-22-2)

Safety Data

• Hazardous Substances Data: 174893-22-2(Hazardous Substances Data)

Upstream product

• 222530-34-9 (1S,3R)-3-((tert-butoxycarbonyl)amino)cyclo hexane-1-carboxylic acid 
• 75-65-0 tert-butyl alcohol 

Downstream Products

• 26772-34-9 (1R,3S)-cyclohexane-1,3-diamine 

Relevant articles and documents

Discovery and structure-activity relationship of 1,3-cyclohexyl amide derivatives as novel mGluR5 negative allosteric modulators

A novel series of trans-1,3-cyclohexyl diamides was discovered and characterized as mGluR5 negative allosteric modulators (NAMs) lacking an alkyne moiety. Conformational constraint of one of the amide bonds in the diamide template led to a spirooxazoline template. A representative compound (24d) showed good in vitro potency, high CNS penetration and, upon subcutaneous dosing, demonstrated efficacy in the mouse marble burying test, generally used as indicative of potential anxiolytic activity.