17512-73-1

Basic information

• Product Name: Benzamide, N-hydroxy-2-methyl- (9CI)
• Synonyms: Benzamide, N-hydroxy-2-methyl- (9CI)
• CAS NO: 17512-73-1
• Molecular Formula: C₈H₉NO₂
• Molecular Weight: 151.16256
• Product Categories: AMIDE
• Mol File: 17512-73-1.mol
• Article Data: 24

Chemical Properties

• Appearance: /
• Density: 1.189±0.06 g/cm3(Predicted)
• PKA: 9.07±0.40(Predicted)
• CAS DataBase Reference: Benzamide, N-hydroxy-2-methyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, N-hydroxy-2-methyl- (9CI)(17512-73-1)
• EPA Substance Registry System: Benzamide, N-hydroxy-2-methyl- (9CI)(17512-73-1)

Safety Data

• Hazardous Substances Data: 17512-73-1(Hazardous Substances Data)

Upstream product

• 75-09-2 dichloromethane 
• 2687-43-6 O-benzylhydoxylamine hydrochloride 
• 622-33-3 N-benzyloxyamine 
• 7087-68-5 N-ethyl-N,N-diisopropylamine 
• 3991-75-1 N-(2-methylbenzoyl)imidazole 
• 529-20-4 2-methylphenyl aldehyde 
• 118-90-1 ortho-methylbenzoic acid 
• 933-88-0 ortho-toluoyl chloride 
• 24424-99-5 di-tert-butyl dicarbonate 
• 89-71-4 2-Methyl-benzoic acid methyl ester 

Downstream Products

• 95-53-4 o-toluidine 
• 1352801-46-7 2-methyl-N-(pivaloyloxy)benzamide 
• 1610376-20-9 2-methyl-N-(pivaloyloxy)-6-((triisopropylsilyl)ethynyl)benzamide 
• 18595-87-4 2-(2-methylphenyl)-4H-3,1-benzoxazin-4-one 
• 94-69-9 2'-methylformanilide 

Relevant articles and documents

Silver-Catalyzed Acyl Nitrene Transfer Reactions Involving Dioxazolones: Direct Assembly of N-Acylureas

Dioxazolones and isocyanides are useful synthetic building blocks, and have attracted significant attention from researchers. However, the silver-catalyzed nitrene transfer reaction of dioxazolones has not been investigated to date. Herein, a silver-catalyzed acyl nitrene transfer reaction involving dioxazolones, isocyanides, and water was realized in the presence of Ag2O to afford a series of N-acylureas in moderate to good yields.

Direct synthesis of benzoxazinones via Cp*Co(III)-catalyzed C–H activation and annulation of sulfoxonium ylides with dioxazolones

A highly novel and direct synthesis of benzoxazinones was developed via Cp*Co(III)-catalyzed C–H activation and [3 + 3] annulation between sulfoxonium ylides and dioxazolones. The reaction is conducted under base-free conditions and tolerates various functional groups. Starting from diverse readily available sulfoxonium ylides and dioxazolones, a variety of benzoxazinones could be synthesized in one step in 32%-75% yields.

Palladium-catalyzed cascade decarboxylative amination/6- endo-dig benzannulation of o-alkynylarylketones with n-hydroxyamides to access diverse 1-naphthylamine derivatives

An efficient and practical one-pot strategy to produce highly substituted 1-naphthylamines via sequential palladium-catalyzed decarboxylative amination/intramolecular 6-endo-dig benzannulation reactions has been described. In this reaction, a broad range of electron-rich, electron-neutral, and electron-deficient o-alkynylarylketones react well with N-hydroxyl aryl/alkylamides to give a diversity of 1-naphthylamines in good to excellent yields under mild reaction conditions. The gram-scale synthesis, with benefits such as undiminished product yield and easy transformation, illustrated the practicality of this method.