175357-57-0Relevant articles and documents
Biologically Inspired Total Synthesis of Ulbactin F, an Iron-Binding Natural Product
Shapiro, Justin A.,Morrison, Kelly R.,Chodisetty, Shreya S.,Musaev, Djamaladdin G.,Wuest, William M.
, p. 5922 - 5926 (2018/09/21)
Natural products from environmental microbiomes provide exquisite templates for elucidating biological activity in the search for new drugs. A recently discovered marine Brevibacillus sp. metabolite, ulbactin F, was found to inhibit tumor cell migration a
Improved total synthesis and biological evaluation of potent apratoxin S4 based anticancer agents with differential stability and further enhanced activity
Chen, Qi-Yin,Liu, Yanxia,Cai, Weijing,Luesch, Hendrik
, p. 3011 - 3029 (2014/05/06)
Apratoxins are cytotoxic natural products originally isolated from marine cyanobacteria that act by preventing cotranslational translocation early in the secretory pathway to downregulate receptor levels and inhibit growth factor secretion, leading to pot
Total synthesis of apratoxin A
Doi, Takayuki,Numajiri, Yoshitaka,Munakata, Asami,Takahashi, Takashi
, p. 531 - 534 (2007/10/03)
We have achieved a total synthesis of apratoxin A in which thiazoline formation was accomplished from the moCys containing amide 4 using PPh 3(O)/Tf2O. Deprotection of the Troc and allyl ester in 17, coupling with tripeptide 3, and d