1333536-66-5Relevant articles and documents
Total Synthesis and Biological Evaluation of Apratoxin e and Its C30 Epimer: Configurational Reassignment of the Natural Product
Wu, Ping,Cai, Weijing,Chen, Qi-Yin,Xu, Senhan,Yin, Ruwen,Li, Yingxia,Zhang, Wei,Luesch, Hendrik
supporting information, p. 5400 - 5403 (2016/11/06)
Apratoxin E provided the inspiration for the design of apratoxin A/E hybrids under preclinical development. Through total synthesis using two different strategies, it was determined that the originally proposed configuration of the thiazoline at C30 is op
Improved total synthesis and biological evaluation of potent apratoxin S4 based anticancer agents with differential stability and further enhanced activity
Chen, Qi-Yin,Liu, Yanxia,Cai, Weijing,Luesch, Hendrik
, p. 3011 - 3029 (2014/05/06)
Apratoxins are cytotoxic natural products originally isolated from marine cyanobacteria that act by preventing cotranslational translocation early in the secretory pathway to downregulate receptor levels and inhibit growth factor secretion, leading to pot