878626-72-3

Upstream product

• 878626-89-2 (S)-Pyrrolidine-1,2-dicarboxylic acid 2-[(1S,3S,5S,6S)-6-((E)-(S)-3-allyloxycarbonyl-1-tritylsulfanylmethyl-but-2-enylcarbamoyl)-1-tert-butyl-5-hydroxy-3-methyl-heptyl] ester 1-(9H-fluoren-9-ylmethyl) ester 
• 17341-93-4 2,2,2-Trichloroethyl chloroformate 
• 878626-87-0 (S)-5,5-dimethyl-4-(4-methoxybenzyloxy)-2-hexanone 
• 878626-77-8 (E)-(S)-5-(4-methoxybenzyloxy)-3,6,6-trimethyl-2-hepten-1-ol 
• 1177263-67-0 pyrrolidine-1,2-dicarboxylic acid (2S)-2-[(1S,3S,5S,6S)-1-tert-butyl-6-carboxy-5-(2,2,2-trichloroethoxycarbonyloxy)-3-methylhept-1-yl]ester 1-(9H-fluoren-9-ylmethyl)ester 
• 676324-76-8 (3S,5S)-5-(4-methoxybenzyloxy)-3,6,6-trimethylheptan-1-ol 
• 676324-77-9 (3R,5S)-5-(4-methoxybenzyloxy)-3,6,6-trimethylheptanal 
• 197454-20-9 (S)-5,5-dimethyl-4-hydroxyhexan-2-one 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 878626-79-0 (E)-(S)-4-tert-butoxycarbonylamino-2-methyl-5-(triphenylmethylthio)pentanoic acid ethyl ether 
• 175357-57-0 tert-butyl (S)-(1-oxo-3-(tritylthio)propan-2-yl)carbamate 
• 878626-76-7 acetic acid 1-[2-(4-methoxy-benzyloxy)-3,3-dimethyl-butyl]-1-methyl-allyl ester 
• 582321-75-3 pyrrolidine-1,2-dicarboxylic acid (2S)-2-[(1S,3S,5S,6S,8R)-8-benzoyloxy-1-tert-butyl-5-(tert-butyldimethylsilyloxy)-3,6-dimethyl-7-oxononyl] ester 1-tert-butyl ester 
• 582321-68-4 pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester (2S)-2-[(1S,3S,5S,6S,8R)-1-tert-butyl-5-(tert-butyldimethylsilyloxy)-6-carboxy-3-methylheptyl] ester 

Downstream Products

• 878626-86-9 pyrrolidine-2-carboxylic acid 1-tert-butyl-6-(4-{2-[1-({1-[(1-carboxy-2-methyl-butyl)-methyl-carbamoyl]-ethyl}-methyl-carbamoyl)-2-(4-methoxy-phenyl)-ethylcarbamoyl]-propenyl}-4,5-dihydro-thiazol-2-yl)-5-hydroxy-3-methyl-heptyl ester 
• 878626-85-8 1-[(9H-fluoren-9-yl)methyl] 2-[(3S,5S,7S,8S)-8-({S}-4-{[5S,8S,11S,E]-11-[(S)-sec-butyl]-5-[4-methoxybenzyl]-2,7,8,10-tetramethyl-3,6,9,12-tetraoxo-13-oxa-4,7,10-triazahexadeca-1,15-dien-1-yl}-4,5-dihydrothiazol-2-yl)-7-hydroxy-2,2,5-trimethylnonan-3-yl] (S)-pyrrolidine-1,2-dicarboxylate 
• 350791-64-9 (-)-apratoxin A 

Relevant academic research and scientific papers

Total synthesis of apratoxin A and B using Matteson's homologation approach

Apratoxin A and B, two members of an interesting class of marine cyclodepsipeptides are synthesized in a straightforward mannerviaMatteson homologation. Starting from a chiral boronic ester, the polyketide fragment of the apratoxins was obtainedviafive su

Total synthesis of (-)-apratoxin A, 34-epimer, and its oxazoline analogue

A concise and convergent total synthesis of the highly cytotoxic marine natural product apratoxin A is accomplished by an 18-step linear sequence. The high sensitivity of the thiazoline, bearing an adjacent β-hydroxyl group at the C35-position, results in

Total synthesis of apratoxin A

We have achieved a total synthesis of apratoxin A in which thiazoline formation was accomplished from the moCys containing amide 4 using PPh 3(O)/Tf2O. Deprotection of the Troc and allyl ester in 17, coupling with tripeptide 3, and d