17576-75-9Relevant academic research and scientific papers
2,2,2-Trifluoroacetophenone as an organocatalyst for the oxidation of tertiary amines and azines to N-oxides
Limnios, Dimitris,Kokotos, Christoforos G.
, p. 559 - 563 (2014)
A cheap, mild and environmentally friendly oxidation of tertiary amines and azines to the corresponding Noxides is reported by using polyfluoroalkyl ketones as efficient organocatalysts. 2,2,2-Trifluoroacetophenone was identified as the optimum catalyst for the oxidation of aliphatic tertiary amines and azines. This oxidation is chemoselective and proceeds in high-to-quantitative yields utilizing 10 mol% of the catalyst and H2O2 as the oxidant.
The first example of catalytic N-oxidation of tertiary amines by tungstate-exchanged Mg-Al layered double hydroxide in water: A green protocol
Choudary,Bharathi,Venkat Reddy,Lakshmi Kantam,Raghavan
, p. 1736 - 1737 (2001)
A green process, using a recyclable tungstate-exchanged Mg-A1 layered double hydroxide (LDH-WO42-) heterogenised catalyst and aqueous H2O2 oxidant in water, leads to N-oxidation of aliphatic tert-amines to amine N-oxides in quantitative yields, at a high rate at room temperature.
Process for the preparation of amine oxides
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Page/Page column 7-8, (2008/06/13)
The present invention provides a process for the preparation of amine oxide by reacting a tertiary or a secondary amine with hydrogen peroxide as an oxidant in the presence of a recyclable heterogeneous catalyst comprising a layered double hydroxide exchanged with an anion in the presence of an additive selected from the group consisting of benzonitrile, propionitrile, isoburyronitrile, benzamide and isobutyramide.
Silicon Polonovski Reaction. Formation and Synthetic Application of α-Siloxy Amines
Tokitoh, Norihiro,Okazaki, Renji
, p. 3291 - 3298 (2007/10/02)
A new and versatile synthetic intermediate, α-siloxy amine was prepared in situ by the base-promoted rearrangement of a siloxyammonium salt obtained by treatment of a tertiary amine N-oxide with trialkylsilyl trifluoromethanesulfonate.The best combination of the base and silylating reagent was found to be methyllithium and t-butyldimethylsilyl trifluoromethanesulfonate.The reactions of α-siloxy amines with acyl halides and haloformates gave the corresponding amides and carbamates in moderate to good yields, respectively.Treatment of α-siloxy amines with acetic acid resulted in a direct dealkylation to free secondary amines.Fluoride induced alkylation of α-siloxy amines using alkyl halides as electrophiles leading to tertiary amines was also examined and demonstrated to be a new transalkylation method of amines.
Effect of geometry on the thermodynamic properties of micellar systems: trialkylamine oxides in water
Caron, Gaston,Gelinas, Nadia,Desnoyers, Jacques E.
, p. 1573 - 1580 (2007/10/02)
The apparent molar volumes, heat capacities, relative enthalpies, and isentropic compressibilities of symmetrical trialkylamine oxides and cyclohexyldimethylamine oxide were measured in water at 25 deg C.The data were in most cases analyzed with a mass-ac
