17583-15-2Relevant academic research and scientific papers
Versatile approaches to a library of building blocks based on 5-acylthiazole skeleton
Kulyk, Olesia G.,Biloborodov, Dmytro A.,Cherevatenko, Maksim A.,Shyriakin, Yevhen Y.,Lyapunov, Alexander Yu.,Mazepa, Alexander V.,Vashchenko, Valerii V.,Orlov, Valeriy D.,Kolosov, Maksim A.
supporting information, p. 3616 - 3628 (2020/09/07)
Thiazole derivatives represent an important class of azole heterocycles with a broad spectrum of biological activity and, therefore, the synthesis of these compounds is of remarkable concern. We present here practical and reliable protocol for synthesis of some 5-acylthiazoles and demonstrate their utility in the preparation of several new series of thiazole-containing building blocks through transformation of 5-acyl function. Specifically, thiazole-based alcohols, oximes, primary, and secondary amines were successively synthesized in good to excellent yields. The chemical structures of obtained compounds were confirmed by 1H and 13C NMR-spectroscopy, elemental analysis, and mass-spectrometry.
A New Heteroannulation Method to 2-Cyclohexenone, Mediated by Phosphonate Auxiliaries. Synthesis of 4,5,6,7-Tetrahydrobenzothiazole Derivatives
Oehler, E.
, p. 763 - 774 (2007/10/02)
Dimethyl (1,2-epoxy-3-oxocyclohex-1-yl)phosphonate 7, easily available from 2-cyclohexen-1-one, affords the new (tetrahydrobenzothiazolyl)phosphonates 10 upon reaction with thiocarboxamides 8.This cyclocondensation proceeds with regioselective conjunction
