175853-53-9Relevant articles and documents
THERAPEUTIC COMPOUNDS
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Page/Page column 32, (2017/08/22)
The present invention relates to compounds that are antagonists of the orexin-1 receptor. The compounds have the structural formula (I) defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or disorders associated with orexin-1 receptor activity.
'N-stereogenic quaternary ammonium salts' from L-amino acids: Synthesis, separation, and absolute configuration
Wu, Hua-Fang,Lin, Wen-Bin,Xia, Li-Zi,Luo, Ying-Gang,Chen, Xiao-Zhen,Li, Guo-You,Zhang, Guo-Lin,Pan, Xin-Fu
experimental part, p. 677 - 688 (2009/08/08)
Diastereoisomeric linear and cyclic 'N-chiral quaternary ammonium salts' (QASs) were efficiently synthesized from corresponding L-amino acids in high yields. The diastereoisomers of each pair of 'N-chiral QASs' were successfully separated. The absolute configurations of these QASs were determined predominately by X-ray single-crystal analysis. The 1H-NMR data of 'N-chiral QASs' provided characteristic information on the configuration of the N-chiral center. 'N-Chiral QASs' exemplified by [N(R)]-2a and [N(S)]-2a are stable in protic and aprotic solvents within a broad pH and temperature range.
Chirale Boran-Amin-Addukte in der asymmetrischen Synthese: Alkylierung von Alaninderivaten
Ferey, Vincent,Toupet, Loic,Gall, Thierry Le,Mioskowski, Charles
, p. 475 - 477 (2007/10/03)
Keywords: Aminosaeuren; Asymmetrische Synthesen; Borverbindungen; Chiralitaet; Enolate
