17603-88-2

Basic information

• Product Name: 2-methyl-6-(1-methylethyl)cyclohexa-2,5-diene-1,4-dione
• Synonyms: 2,5-Cyclohexadiene-1,4-dione, 2-methyl-6-(1-methylethyl)-
• CAS NO: 17603-88-2
• Molecular Formula: C₁₀H₁₂O₂
• Molecular Weight: 164.2011
• Mol File: 17603-88-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 232°C at 760 mmHg
• Flash Point: 84.4°C
• Density: 1.065g/cm³
• Vapor Pressure: 0.0603mmHg at 25°C
• Refractive Index: 1.504
• CAS DataBase Reference: 2-methyl-6-(1-methylethyl)cyclohexa-2,5-diene-1,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-6-(1-methylethyl)cyclohexa-2,5-diene-1,4-dione(17603-88-2)
• EPA Substance Registry System: 2-methyl-6-(1-methylethyl)cyclohexa-2,5-diene-1,4-dione(17603-88-2)

Safety Data

• Hazardous Substances Data: 17603-88-2(Hazardous Substances Data)

Upstream product

• 72-18-4 L-valine 
• 553-97-9 2-Methyl-1,4-benzoquinone 
• 78-84-2 isobutyraldehyde 
• 79-31-2 isobutyric Acid 
• 3228-02-2 3-Methyl-4-isopropylphenol 
• 3228-03-3 3-isopropyl-5-methylphenol 
• 3228-04-4 2-methyl-6-isopropyl phenol 

Downstream Products

• 133447-23-1 2-isopropyl-6-methylbenzene-1,4-diol 

Relevant articles and documents

Quinone C-H Alkylations via Oxidative Radical Processes

A brief survey of radical additions to quinones is reported. Carboxylic acids, aldehydes, and unprotected amino acids are compared as alkyl radical precursors for the mono- or bis- C-H alkylation of several quinones. Two methods for radical initiation are discussed comparing inorganic persulfates and Selectfluor as stoichiometric oxidants. Kinetic analysis reveals dramatic differences in the rate of radical initiation depending on the identity of the radical precursor and oxidant. Synthetic strategies for efficiently producing alkyl-quinones are discussed in the context of selecting optimum radical precursors and initiators depending on quinone identity and functional groups present.

Ruthenium-catalyzed oxidative dearomatization of phenols to 4-(tert-butylperoxy)cyclohexadienones: Synthesis of 2-substituted quinones from p-substituted phenols

The ruthenium-catalyzed oxidation of phenols with tert-butylhydroperoxide efficiently gives the corresponding 4-(tert-butylperoxy)cyclohexadienones. The oxidation proceeds selectively because of ruthenium's ability for rapid single-electron transfer. This biomimetic oxidation reaction is highly useful to obtain the metabolic compounds desired for confirming the safety of medicines and related compounds. Typically, the first metabolic compound of the female hormone estrone is readily obtained by this biomimetic oxidation reaction. The resulting 4-(tert-butylperoxy)cyclohexadienones are versatile synthetic intermediates, which can be transformed into 2-substituted 1,4-benzoquinones by treatment with acid catalysts. Acid-promoted rearrangement followed by a Diels-Alder reaction provides a new strategy for the synthesis of fused cyclic compounds, such as naphthoquinone and anthraquinone derivatives, from readily available phenols. The nonnatural 1,4-diacetoxy steroidal skeleton is obtained by the oxidation of estrone followed by zinc-mediated migration. Vitamin K 3 is synthesized selectively from p-cresol in an overall 79 % yield in 4 steps, and the synthesis includes the ruthenium-catalyzed oxidation.

Synthesis of a novel class of water-soluble and bioavailable antioxidants: 5-Hydroxycoumaran derivatives possessing imidazole group

The 5-hydroxycoumaran derivative 1 possessing imidazole group was synthesized from 2-isopropyl-6-methylphenol with high regioselectivity. The compound 1 was the water-soluble antioxidant with potent bioavailability and showed TXA2 synthase inhibition.